A kinase sequence database: sequence alignments and family assignment
A kinase sequence database: sequence alignments and family assignment
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DOI：
10.1093/bioinformatics/18.9.1274
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发表时间：
2002-09-01
期刊：
影响因子：
5.8
通讯作者：
Shokat, KM
中科院分区：
文献类型：
--
作者：
Buzko, O;Shokat, KM
激酶序列数据库（KSD）位于http://kinase.ucsf.edu/ksd，包含290个蛋白激酶家族的信息，这些家族是通过对从GenBank范围内搜索获得的非冗余序列列表进行基于图谱的聚类而获得的。数据库中包括来自100多种生物的5041种蛋白激酶。根据激酶催化结构域（长度为250-300个残基）内的同源性程度聚类成家族。通过基于Excel的交互式序列电子表格查看族的对齐。此外，KSD还提供了每个家族的进化树和每个序列的详细信息，以及与相应GenBank条目的链接。还提供了序列操作工具，如进化树生成、新序列分配和统计分析。
The Kinase Sequence Database (KSD) located at http://kinase.ucsf.edu/ksd contains information on 290 protein kinase families derived by profile-based clustering of the non-redundant list of sequences obtained from a GenBank-wide search. Included in the database are a total of 5041 protein kinases from over 100 organisms. Clustering into families is based on the extent of homology within the kinase catalytic domain (250-300 residues in length). Alignments of the families are viewed by interactive Excel-based sequence spreadsheets. In addition, KSD features evolutionary trees derived for each family and detailed information on each sequence as well as links to the corresponding GenBank entries. Sequence manipulation tools, such as evolutionary tree generation, novel sequence assignment, and statistical analysis, are also provided.