Mendelian randomization study on the causal effects of omega-3 fatty acids on rheumatoid arthritis
Mendelian randomization study on the causal effects of omega-3 fatty acids on rheumatoid arthritis
复制标题
Omega-3 脂肪酸对类风湿性关节炎因果影响的孟德尔随机研究。
DOI：
10.1007/s10067-022-06052-y
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发表时间：
2022-01-08
影响因子：
3.4
通讯作者：
Wang, Renxi
中科院分区：
文献类型：
--
作者：
Zhu, Gaizhi;Zhou, Shan;Wang, Renxi
目的为了解决关于血浆omega-3脂肪酸在类风湿关节炎（RA）中作用的持续争论，我们试图确定omega-3摄入量与RA风险之间的关联。方法我们分析了来自最大的omega-3脂肪酸全基因组关联研究（GWAS）的数据（N = 114，999例欧洲血统）和RA（14，361例欧洲血统病例和43，923例对照）。采用Mendelian随机化-egger_intercept、MR-SPOT和Cochran's Q检验确定多效性和异质性。Egger，加权中位数，逆方差加权（IVW），简单模式，加权模式被用来评估的因果关系的血浆omega-3水平RA。结果我们发现没有显着的多效性，异质性，和偏差之间的omega-3遗传工具变量（IV）在RA GWAS数据集。MR分析表明，随着omega-3水平的遗传增加，MS的风险增加，（Beta = 0.137，p = 0.037; OR = 1.146，95% CI：[1.014，1.296]），加权中位数（Beta = 0.162，p = 0.001; OR = 1.176，95%CI：[1.070，1.292]），IVW（Beta = 0.102，p = 0.025; OR = 1.108，95% CI：[1.013，1.211]），简单模式（Beta = 0.219，p = 0.149; OR = 1.245，95%CI：[0.931，1.665]），加权模式（Beta = 0.146，p = 0.006; OR = 1.157，95%CI：[1.051，1.274]）.结论我们的分析表明，在欧洲血统人群中，遗传性血浆omega-3水平升高与RA风险增加之间存在因果关系。因此，为了降低RA的风险，欧洲血统的人应该减少omega-3的摄入量。
Objectives To resolve the ongoing debate on the role of plasma omega-3 fatty acids in rheumatoid arthritis (RA), we attempted to identify the association between omega-3 intake and the risk of RA.Methods We analyzed data from the largest genome-wide association study (GWAS) for omega-3 fatty acids (N = 114,999 of European ancestry) and RA (14,361 cases and 43,923 controls of European ancestry). Mendelian randomization-egger_intercept, MR-PRESSO, and Cochran's Q test were used to determine pleiotropy and heterogeneity. Egger, weighted median, inverse variance weighted (IVW), simple mode, and weighted mode were used to evaluate the causal association of plasma omega-3 levels on RA.Results We found no significant pleiotropy, heterogeneity, and bias among the omega-3 genetic instrumental variables (IVs) in RA GWAS datasets. MR analysis demonstrated that as omega-3 levels genetically increased, the risk of MS increased using MR-egger (Beta = 0.137, p = 0.037; OR = 1.146, 95% CI: [1.014, 1.296]), weighted median (Beta = 0.162,p = 0.001; OR = 1.176, 95% CI: [1.070, 1.292]), IVW (Beta = 0.102, p = 0.025; OR = 1.108, 95% CI: [1.013, 1.211]), simple mode (Beta = 0.219,p = 0.149; OR = 1.245, 95% CI: [0.931, 1.665]), and weighted mode (Beta = 0.146, p = 0.006; OR = 1.157, 95% CI: [1.051, 1.274]).Conclusions Our analysis suggested a causal association between genetically increased plasma omega-3 levels and the increased risk of RA in populations with European ancestry. Thus, to reduce the risk of RA, those of European descent should reduce omega-3 intake.