Pleomorphic adenoma of the larynx.
Pleomorphic adenoma of the larynx.
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DOI：
10.14744/nci.2015.47965
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发表时间：
2016
影响因子：
1
通讯作者：
Şahin Ş
中科院分区：
文献类型：
--
作者：
Altunpulluk MD;Karabulut MH;Kır G;Şahin Ş
多形性腺瘤是唾液腺最常见的良性肿瘤。它通常发生在主要的唾液腺，如腮腺和下颌腺。然而，偶尔也会发生在喉部。这些病变通常表现为生长缓慢、无痛的肿块。恶性转化非常罕见，但随着时间的推移而增加。本报告是一名59岁男性的病例，他提出了声音嘶哑的投诉。右侧垂直半喉部分切除术显示喉声门上区一完整的粘膜覆盖肉质2×1.5×1 cm肿块。病变具有PA的组织学特征，细胞角蛋白、S100蛋白、胶质纤维酸性蛋白（GFAP）和vimentin的免疫组化表达证实了这一点。然而，他们的组织病理学鉴定并不总是直截了当的；免疫组织化学对明确诊断的制定和适当随访的实现具有重要意义。
Pleomorphic adenoma (PA) is the most common benign neoplasm of the salivary glands. It usually occurs in major salivary glands, such as the parotid and submandibular glands. Occasionally, however, it occurs in the larynx. These lesions generally present as a slow-growing, painless mass. Malignant transformation is very rare, but it increases with time. The present report is the case of a 59-year-old male who presented with a complaint of hoarseness. Right vertical partial hemilaryngectomy revealed an intact, mucosa-covered, fleshy 2×1.5×1 cm mass in the supraglottic area of the larynx. Lesion had histological characteristics of a PA, and this was confirmed by immunohistochemical expression of cytokeratin, S100 protein, Glial fibrillary acidic protein (GFAP) and vimentin. Their histopathological identification is, however, not always straightforward; immunohistochemistry can contribute significantly to formulation of a definitive diagnosis and to the realization of appropriate follow-up.