Spatial and temporal organization during cardiac fibrillation
Spatial and temporal organization during cardiac fibrillation
复制标题
DOI：
10.1038/32164
复制
发表时间：
1998-03-05
期刊：
影响因子：
64.8
通讯作者：
Jalife, J
中科院分区：
文献类型：
--
作者：
Gray, RA;Pertsov, AM;Jalife, J
心脏纤维性颤动（心肌纤维的自发、异步收缩）是工业化国家的主要死因（1），但它是如何发生的尚不清楚。纤颤是否是一种随机现象一直存在争议。在纤维性颤动（2，3）期间存在某种确定性，可能是由电活动的旋转波引起的（4-6）。在这里，我们提出了一种新的算法，显着减少所需的数据量来描绘复杂的时空模式的纤颤。我们使用电位染料（7）和视频成像（8，9）记录纤颤过程中许多部位的跨膜电位动态。在每个站点的跨膜信号表现出强的周期性成分集中在8 Hz附近。这种周期性被视为二维相空间中的吸引子，并且每个位点可以由其在吸引子周围的相位来表示。每个时刻的空间相位图以拓扑缺陷或相位奇点的形式揭示了在一些位点处的纤颤的“来源”。使用我们的方法来识别相位奇点，我们可以阐明这些奇点的形成和终止的机制，并通过定位奇点来表示一段纤颤。我们的研究结果表明，在心脏颤动的时间和空间组织前所未有的数量。
Cardiac fibrillation (spontaneous, asynchronous contractions of cardiac muscle fibres) is the leading cause of death in the industrialized world(1), yet it is not dear how it occurs. It has been debated whether or not fibrillation is a random phenomenon. There is some determinism during fibrillation(2,3), perhaps resulting from rotating waves of electrical activity(4-6). Here we present a new algorithm that markedly reduces the amount of data required to depict the complex spatiotemporal patterns of fibrillation. We use a potentiometric dye(7) and video imaging(8,9) to record the dynamics of transmembrane potentials at many sites during fibrillation. Transmembrane signals at each site exhibit a strong periodic component centred near 8 Hz. This periodicity is seen as an attractor in two-dimensional-phase space and each site can be represented by its phase around the attractor, Spatial phase maps at each instant reveal the 'sources' of fibrillation in the form of topological defects, or phase singularities(10), at a few sites. Using our method of identifying phase singularities, we can elucidate the mechanisms for the formation and termination of these singularities, and represent an episode of fibrillation by locating singularities. Our results indicate an unprecedented amount of temporal and spatial organization during cardiac fibrillation.