Trinucleotide repeat polymorphism within exon 5 of the MICA gene (MHC class I chain-related gene A): allele frequency data in the nine population groups Japanese, Northern Han, Hui, Uygur, Kazakhstan, Iranian, Saudi Arabian, Greek and Italian
Trinucleotide repeat polymorphism within exon 5 of the MICA gene (MHC class I chain-related gene A): allele frequency data in the nine population groups Japanese, Northern Han, Hui, Uygur, Kazakhstan, Iranian, Saudi Arabian, Greek and Italian
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DOI：
10.1111/j.1399-0039.1997.tb02778.x
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发表时间：
1997-05-01
期刊：
影响因子：
--
通讯作者：
Inoko, H
中科院分区：
文献类型：
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作者：
Ota, M;Katsuyama, Y;Inoko, H
我们最近发现了一个三核苷酸重复多态性，（GCT）n，在跨膜（TM）段的人MHC I类云母基因（MHC I类链相关基因A）。在各种HLA纯合B细胞系中检测到5种不同的等位基因（A4、A5、A5.1、A6、A9），分别对应于4、5、5个核苷酸插入、6和9个重复。本文采用聚合酶链反应（PCR）结合荧光自动片段检测技术，对来自9个人群（日本、北方汉族、回族、维吾尔族、哈萨克斯坦、伊朗、沙特阿拉伯、希腊和意大利）的604名无关个体的STR基因频率进行了检测。所有的等位基因都存在于每个群体中，但等位基因的分布从一个群体到另一个不同。未发现新的等位基因（如A7或A8）。这些数据的进化和结构的意义以及法医学的潜在应用进行了讨论。
We recently identified a trinucleotide repeat polymorphism, (GCT)n, within the transmembrane (TM) segment of the human MHC class I MICA gene (MHC class I chain-related gene A). Five distinct alleles (A4, A5, A5.1, A6, A9) corresponding to 4, 5, 5 with one nucleotide insertion, 6 and 9 repetitions, respectively, have been detected in various HLA homozygous B cell lines. Here we present allele frequencies for this trimeric short tandem repeat (STR) in 604 unrelated individuals collected from nine human populations (Japanese, Northern Han, Hui, Uygur, Kazakhstan, Iranian, Saudi Arabian, Greek and Italian) determined using the polymerase chain reaction (PCR) combined with fluorescent-based automated fragment detection technology. All alleles were present in each population, but allelic distributions varied from one population to another. No new alleles (such as A7 or A8) were identified. The evolutionary and structural significance of these data as well as the potential application to forensic medicine is discussed.