ANKLE-ARM INDEX AS A MARKER OF ATHEROSCLEROSIS IN THE CARDIOVASCULAR HEALTH STUDY
ANKLE-ARM INDEX AS A MARKER OF ATHEROSCLEROSIS IN THE CARDIOVASCULAR HEALTH STUDY
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DOI：
10.1161/01.cir.88.3.837
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发表时间：
1993-09-01
期刊：
影响因子：
37.8
通讯作者：
WOLFSON, SK
中科院分区：
文献类型：
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作者：
NEWMAN, AB;SISCOVICK, DS;WOLFSON, SK
背景。通过踝臂指数（AAI）无创测量的外周动脉疾病在老年人中很常见，大部分无症状，并且与临床明显的心血管疾病（CVD）相关。之前的研究中，异常 AAI 的标准各不相同。为了确定 AAI 与临床 CVD、亚临床疾病和危险因素之间是否存在反向剂量反应关系，我们检查了 AAI 与心血管危险因素、使用颈动脉超声、超声心动图和心电图的其他非侵入性亚临床动脉粥样硬化测量以及临床 CVD 的关系。方法和结果。在心血管健康研究的基线检查中，对 5084 名大于或等于 65 岁的参与者进行了 AAI 测量。所有受试者均对流行的 CVD、心血管危险因素的测量以及疾病的非侵入性测量进行了详细的评估。参与者根据基线临床 CVD 状态和 AAI 进行分层（
Background. Peripheral arterial disease measured noninvasively by the ankle-arm index (AAI) is common in older adults, largely asymptomatic, and associated with clinically manifest cardiovascular disease (CVD). The criteria for an abnormal AAI have varied in previous studies. To determine whether there is an inverse dose-response relation between the AAI and clinical CVD, subclinical disease, and risk factors, we examined the relation of the AAI to cardiovascular risk factors, other noninvasive measures of subclinical atherosclerosis using carotid ultrasound, echocardiography and electrocardiography, and clinical CVD.Methods and Results. The AAI was measured in 5084 participants greater-than-or-equal-to 65 years old at the baseline examination of the Cardiovascular Health Study. All subjects had detailed assessment of prevalent CVD, measures of cardiovascular risk factors, and noninvasive measures of disease. Participants were stratified by baseline clinical CVD status and AAI (