Sclerosing cholangitis associated to cryptosporidiosis in liver-transplanted children
Sclerosing cholangitis associated to cryptosporidiosis in liver-transplanted children
复制标题
肝移植儿童中与隐孢子虫病相关的硬化性胆管炎
DOI：
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发表时间：
2000
影响因子：
3.6
通讯作者：
E. Sokal
中科院分区：
文献类型：
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作者：
M. Campos;E. Jouzdani;C. Sempoux;J. Buts;R. Reding;J. Otte;E. Sokal
摘要461例小儿肝移植受者中有3例发生了与肠道隐孢子虫携带相关的弥漫性胆管炎。所有三人都接受了他克莫司和泼尼松组成的免疫抑制剂。冷孢子虫携带用巴龙霉素处理，而根据移植耐受性降低免疫抑制。未发现其他感染性病原体，也未检测到血管问题。三人均再次进行了胆管吻合术，但一名患者出现胆汁性肝硬化，需要再次移植。所有三名患者都活得很好，随访时没有肠道寄生虫。
结论隐孢子虫肠道感染可能在肝移植患儿不明原因的胆道疾病中起一定作用。这可能导致严重的发病率，包括需要再次移植。
Abstract Three children of a series of 461 pediatric liver transplant recipients developed diffuse cholangitis associated with intestinal cryptosporidium carriage. All three received immunosuppression consisting of tacrolimus and prednisone. Cryprosporidium carriage was treated with paramomycin, while immunosuppression was decreased according to graft tolerance. No other infectious pathogens were found, and no vascular problems were detected. Bile duct anastomosis was reoperated in all three, but biliary cirrhosis developed in one patient, requiring retransplantation. All three patients are alive and well, and free of intestinal parasites on follow-up.
Conclusion Cryptosporidium intestinal infection may play a role in some cases of otherwise unexplained cholangiopathies in pediatric liver transplant recipients. This may lead to significant morbidity, including need for retransplantation.
影响因子：
4.4
作者：
A. Hayward;J. Levy;F. Facchetti;L. Notarangelo;H. Ochs;Amos Etzioni;J. Bonnefoy;M. Cosyns;A. Weinberg
通讯作者：
A. Hayward;J. Levy;F. Facchetti;L. Notarangelo;H. Ochs;Amos Etzioni;J. Bonnefoy;M. Cosyns;A. Weinberg