Daily, limited access to methamphetamine self-administration during pregnancy leads to increased methamphetamine sensitivity in adult offspring.
Daily, limited access to methamphetamine self-administration during pregnancy leads to increased methamphetamine sensitivity in adult offspring.
复制标题
怀孕期间每天自行服用甲基苯丙胺的机会有限，会导致成年后代对甲基苯丙胺的敏感性增加。
DOI：
10.1002/dev.22350
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发表时间：
2023
影响因子：
2.2
通讯作者：
Rüedi-Bettschen,Daniela
中科院分区：
文献类型：
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作者：
Pareek,Tanya;Platt,DonnaM;Rüedi-Bettschen,Daniela
妇女使用甲基苯丙胺，甚至在整个怀孕期间也很常见。但是，关于产前甲基苯丙胺暴露儿童的影响的知识有限。本研究调查了与对照组相比，大鼠产前甲基苯丙胺暴露（通过母体静脉自我给药）如何影响成年后代对甲基苯丙胺的敏感性。在妊娠前和整个妊娠期间，在有限接触条件下每日自我给予甲基苯丙胺的母鼠或其各自的盐水轭对照母鼠产生后代。在一系列甲基苯丙胺剂量后，评估了两个暴露组的雄性和雌性后代的自发和甲基苯丙胺诱导的运动活动。在一组单独的后代中，评估了静脉注射甲基苯丙胺自我给药的获得，在甲基苯丙胺强化的固定和渐进比例方案下的反应，以及消失的药物寻求行为的恢复。甲基苯丙胺剂量依赖性增加两个暴露组的自发活动。然而，与对照组相比，1 mg/kg甲基苯丙胺暴露雄性动物的自发活动显著增强，与对照组相比，3.2 mg/kg甲基苯丙胺暴露雌性动物的自发活动显著增强。与对照组相比，两种性别的甲基苯丙胺暴露后代获得甲基苯丙胺自我给药的速度更快，并且显示出甲基苯丙胺诱导的恢复水平总体更高。总之，这些结果表明，产前甲基苯丙胺暴露于相对较低的水平改变甲基苯丙胺的敏感性，在男性和女性成年后代。
Methamphetamine use by women, even throughout pregnancy, is common. But there is limited knowledge about the effects in prenatally methamphetamine‐exposed children. This study investigated how prenatal methamphetamine exposure in rats, via maternal i.v. self‐administration, affected the sensitivity of adult offspring to methamphetamine in comparison with controls. The offspring were generated from dams either self‐administering methamphetamine daily under limited‐access conditions prior to and throughout pregnancy, or their respective saline‐yoked control dams. Spontaneous and methamphetamine‐induced locomotor activity was assessed in male and female offspring of both exposure groups after a range of methamphetamine doses. In a separate group of offspring, acquisition of i.v. methamphetamine self‐administration, responding under fixed and progressive ratio schedules of methamphetamine reinforcement, and reinstatement of extinguished drug‐seeking behavior were assessed. Methamphetamine dose‐dependently increased locomotor activity in both exposure groups. However, methamphetamine‐exposed males showed significantly enhanced locomotor activity compared with controls at 1 mg/kg, and methamphetamine‐exposed females showed significantly enhanced locomotor activity compared with controls at 3.2 mg/kg. Methamphetamine‐exposed offspring of both sexes acquired methamphetamine self‐administration faster and showed overall higher levels of methamphetamine‐induced reinstatement compared with controls. Taken together, these results indicate that prenatal methamphetamine exposure to relatively low levels alters methamphetamine sensitivity in male and female adult offspring.