Reward Processing and Risk for Depression Across Development.
Reward Processing and Risk for Depression Across Development.
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DOI：
10.1016/j.tics.2016.04.002
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发表时间：
2016-06
影响因子：
19.9
通讯作者：
Barch DM
中科院分区：
文献类型：
--
作者：
Luking KR;Pagliaccio D;Luby JL;Barch DM
纹状体对奖赏的反应在典型的发育和精神病理学文献中引起了极大的兴趣。这些平行的调查表明，虽然通常发育中的青少年对奖励表现出强烈的纹状体反应，但患有重度抑郁症（MDD）或MDD高风险的青少年对奖励表现出迟钝的反应。了解这些发现如何相互交叉对于在高危儿童中开发和应用早期预防干预措施至关重要，理想情况下，在青春期发生的MDD发病率急剧增加之前。强有力的研究结果有关钝纹状体反应奖励和MDD风险进行审查，并位于一个规范的发展背景下。我们强调需要进一步的研究调查纵向发展，特异性MDD，和潜在的主持人和调解人的角色。
Striatal response to reward has been of great interest in the typical development and psychopathology literatures. These parallel lines of inquiry demonstrate that while typically developing adolescents show robust striatal response to reward, adolescents with major depressive disorder (MDD) or those at high-risk for MDD show blunted response to reward. Understanding how these findings intersect is critical for the development and application of early preventative interventions in at-risk children, ideally before the sharp increase in the rate of MDD onset that occurs in adolescence. Robust findings relating blunted striatal response to reward and MDD-risk are reviewed and situated within a normative developmental context. We highlight the need for future studies investigating longitudinal development, specificity to MDD, and roles of potential moderators and mediators.