Neither antioxidants nor genistein inhibit the progression of established atherosclerotic lesions in older apoE deficient mice.
Neither antioxidants nor genistein inhibit the progression of established atherosclerotic lesions in older apoE deficient mice.
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DOI：
10.1016/j.atherosclerosis.2008.06.017
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发表时间：
2009-03
期刊：
影响因子：
5.3
通讯作者：
Rosenfeld, Michael E.
中科院分区：
文献类型：
--
作者：
Averill, Michelle M.;Bennett, Brian J.;Rattazzi, Marcello;Rodmyre, Rebecca M.;Kirk, Elizabeth A.;Schwartz, Stephen M.;Rosenfeld, Michael E.
Antioxidants and soy isoflavones inhibit the development of fatty streaks in various animal models. However, clinical trials in humans have not entirely supported a cardio-protective role for antioxidants or isoflavones. Thus, we examined the effects of antioxidants and genistein on the progression and composition of established, advanced atherosclerotic lesions in the innominate arteries (IA) of older apolipoprotein E-deficient (apoE-/-) mice. Thirty week old male apoE-/- mice were fed chow with or without genistein (0.27% w/w) for 6, 12 and 24 weeks. Twenty week old male apoE-/- mice were fed chow with or without a cocktail of antioxidants (vitamin E 0.2% w/w, vitamin C 0.05% w/w, and beta carotene 0.5% w/w) for 10, 16, and 22 weeks. There were no significant differences in total plasma cholesterol, body weight, average area of the lesion or media, or changes in lesion composition with either treatment in comparison to chow-fed control mice. This data may help explain why there have not been consistent protective effects of antioxidants and isoflavones on cardiovascular disease in human clinical trials.
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影响因子：
4.8
作者：
Kuiper, GGJM;Lemmen, JG;Gustafsson, JÄ
通讯作者：
Gustafsson, JÄ
影响因子：
4.2
作者：
Kirk, EA;Sutherland, P;LeBoeuf, RC
通讯作者：
LeBoeuf, RC
影响因子：
4.2
作者：
Ni, WH;Tsuda, Y;Imaizumi, K
通讯作者：
Imaizumi, K
影响因子：
6.1
作者：
Rüfer, CE;Kulling, SE
通讯作者：
Kulling, SE
影响因子：
158.5
作者：
RIMM, EB;STAMPFER, MJ;WILLETT, WC
通讯作者：
WILLETT, WC