Label-free in vivo fiber-based optical-resolution photoacoustic microscopy
Label-free in vivo fiber-based optical-resolution photoacoustic microscopy
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DOI：
10.1364/ol.36.004107
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发表时间：
2011-10-15
期刊：
影响因子：
3.6
通讯作者：
Zemp, R. J.
中科院分区：
文献类型：
--
作者：
Hajireza, P.;Shi, W.;Zemp, R. J.
在这封信中，无标记的光纤为基础的光学分辨率光声显微镜的能力证明。这种实时成像系统利用了图像引导光纤和独特的光纤激光器。800 μ m的图像引导由30，000个单独的单模光纤束和二极管泵浦，脉冲镱光纤激光器被用来执行高达600 kHz的重复率。体模研究表明7 μ m的分辨率。所提出的设置保持了以前的桌面OR-PAM系统的许多强大特性，但由于图像引导的性质，还提供了亚毫米探头足迹和高灵活性。该系统可能对内窥镜应用具有显著的临床影响，其中细纤维可以插入体内。(C)2011年美国光学学会
In this Letter, the capability of label-free fiber-based optical-resolution photoacoustic microscopy is demonstrated. This real-time imaging system takes advantage of image-guide fibers and a unique fiber laser. The 800 mu m image-guide consists of 30,000 individual single-mode fibers in a bundle and the diode-pumped, pulsed Ytterbium fiber laser is utilized to perform up to 600 kHz repetition rate. Phantom studies indicate 7 mu m resolution. The proposed setup keeps many of the powerful properties of previous tabletop OR-PAM systems, but also offers a submillimeter probe footprint and high flexibility due to the nature of the image-guide. This system could have significant clinical impact for endoscopic applications where the thin fiber can be inserted into the body. (C) 2011 Optical Society of America