Long non-coding RNAs in thyroid cancer: Biological functions and clinical significance
Long non-coding RNAs in thyroid cancer: Biological functions and clinical significance
复制标题
甲状腺癌中长链非编码RNA的生物学功能和临床意义
DOI：
10.1016/j.mce.2017.07.020
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发表时间：
2018-07-05
影响因子：
4.1
通讯作者：
Hou, Peng
中科院分区：
文献类型：
--
作者：
Sui, Fang;Ji, Meiju;Hou, Peng
甲状腺癌是最常见的内分泌恶性肿瘤，近几十年来发病率迅速上升。虽然大多数甲状腺癌是相对惰性的，但有些病例仍有发展成更具侵略性和致命性的甲状腺癌的风险。与其他恶性肿瘤相似，甲状腺肿瘤的发生是一个多步骤的过程，涉及大量遗传和表观遗传改变的积累。因此，确定肿瘤发生的机制是甲状腺癌治疗的迫切需要。长链非编码RNA（LncRNA）最近被证明参与癌症进展。然而，它们在甲状腺癌中的作用和分子机制在很大程度上仍不清楚。本文就lncRNA在甲状腺癌中的表达异常进行综述，并对lncRNA在甲状腺癌中的作用及机制的最新研究进展进行总结，探讨其在甲状腺癌诊断及预后判断中的潜在临床意义。(C)2017爱思唯尔B.V.保留所有权利。
Thyroid cancer is the most common endocrine malignant tumor with rapidly increasing incidence in recent decades. Although the majority of thyroid cancers are relatively indolent, some cases still have a risk of developing into more aggressive and lethal forms of thyroid cancers. Similar to other malignancies, thyroid tumorigenesis is a multistep process involving the accumulation of a large number of genetic and epigenetic alterations. Thus, determination of the mechanisms of tumorigenesis is an urgent need for thyroid cancer treatment. Long noncoding RNAs (LncRNAs) have recently been demonstrated to participate in cancer progression. However, their role and molecular mechanism in thyroid cancer remain largely unclear. In this review, we focus on the dysregulation of lncRNAs in thyroid cancer, summarize the latest findings regarding the functions and mechanism of lncRNAs in thyroid cancer, and discuss their potential clinical significance in diagnosis and prognosis of thyroid cancer. (C) 2017 Elsevier B.V. All rights reserved.