The rates of chemotherapy-induced amenorrhea in patients treated with adjuvant doxorubicin-and cyclophosphamide followed by a taxane
The rates of chemotherapy-induced amenorrhea in patients treated with adjuvant doxorubicin-and cyclophosphamide followed by a taxane
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DOI：
10.1097/01.coc.0000251398.57630.4f
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发表时间：
2007-04-01
影响因子：
2.6
通讯作者：
Kramer, Rita
中科院分区：
文献类型：
--
作者：
Tham, Yee-Lu;Sexton, Krystal;Kramer, Rita
目的：绝经前乳腺癌辅助化疗可导致闭经，影响生育能力，影响激素治疗的选择，增加晚期毒性风险。阿霉素和环磷酰胺（AC）后紫杉烷(T)引起的化疗性闭经（CIA）的发生率尚不清楚。方法：我们回顾性调查了绝经前和化疗开始时年龄小于50岁的妇女，以确定接受AC联合T治疗的妇女与单独接受AC治疗的妇女的CIA发生率。结果：191名符合条件的女性完成了调查。接受AC后再接受T治疗的女性CIA发生率为64%(95%可信区间[CI] = 55-72%)，而单独接受AC治疗的女性CIA发生率为55% （95% CI = 43-66%）。正如预期的那样，老年女性的CIA发生率高于年轻女性（82%对55%，P = 0.004）。多因素logistic回归分析显示，年龄在50至40岁之间的CIA风险增加4.6倍（95% CI = 1.7-12）。1, p = 0.002)。研究还显示，与单独接受AC相比，AC后接受T治疗与CIA的比值比为1.9 （95% CI = 1.0-3.5, P = 0.05）。尽管>= 6个月闭经，许多妇女>= 40恢复月经（40%）。中情局在那个年代更有可能是不可逆转的。紫杉烷的加入并没有改变整个组的可逆性（P = 0.36）。结论：年龄的增长和紫杉烷的加入增加了CIA的风险，女性闭经更可能是不可逆的[40]。女性
Objective: Adjuvant chemotherapy in premenopausal women with breast cancer may induce amenorrhea, which can affect fertility, choice of hormonal therapy, and increase the risk of late toxicity. The incidence of chemotherapy-induced amenorrhea (CIA) resulting from doxorubicin and cyclophosphamide (AC) followed by a taxane (T) is poorly characterized.Methods: We retrospectively surveyed women who were premenopausal and less than age 50 at initiation of chemotherapy to determine the rates of CIA in women receiving AC followed by T compared with AC alone.Results: One hundred ninety-one eligible women completed the survey. The rate of CIA in women who received AC followed by T was 64% (95% confidence interval [CI] = 55-72%) compared with 55% (95% CI = 43-66%) in AC alone. As expected, CIA rates were higher in older than younger women (82% vs. 55%, P = 0.004). Multivariate logistic regression analysis revealed that age >40 was associated with a 4.6-fold increased risk of CIA (95% CI = 1.7-12. 1, P = 0.002). It also revealed that receiving T after AC was associated with an odds ratio of 1.9 for CIA as compared with receiving AC alone (95% CI = 1.0-3.5, P = 0.05). Despite >= 6 months of amenorrhea, many women >= 40 resumed menses (40%). CIA was more likely to be irreversible in those >40. The addition of taxanes did not alter the rate of reversibility for the group as a whole (P = 0.36).Conclusions: Older age and the addition of taxane to AC increased the risk of CIA and the amenorrhea was more likely to be irreversible for women >40. Women