EXTENDED REPORT Associations between Statin use and changes in pain, function and structural progression: a longitudinal study of persons with knee osteoarthritis
EXTENDED REPORT Associations between Statin use and changes in pain, function and structural progression: a longitudinal study of persons with knee osteoarthritis
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DOI：
10.1136/annrheumdis-2012-202159
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发表时间：
2013-02-01
影响因子：
27.4
通讯作者：
Dumenci, Levent
中科院分区：
文献类型：
--
作者：
Riddle, Daniel L.;Moxley, George;Dumenci, Levent
目的最近发表的研究表明，他汀类药物可能对膝骨性关节炎(OA)患者具有有益的结构效应。他汀类药物对患者报告的膝关节疼痛和功能的潜在影响尚未得到检验。我们对一大批基于社区的膝关节骨性关节炎患者进行了前瞻性研究，以确定他汀类药物的使用是否与膝关节结构、疼痛和功能轨迹的改变有关。方法数据来自骨关节炎倡议，数据来自2207名经放射学怀疑或确诊的膝关节骨性关节炎患者。观察4年来西安大略省和麦克马斯特大学关节炎指数(WOMAC)疼痛和身体功能评分、疼痛强度和Kellgren-Lawrence放射学分级的变化。来自个人的数据根据他们是否在4年内使用他汀类药物进行编码。结果轨迹和他汀类药物的使用概率在4年的研究期间通过平行处理生长曲线模型进行了检验。结果使用他汀类药物的患者在第1年和第4年分别占样本的6.7%和16.4%。他汀类药物的使用与膝关节疼痛、功能或结构进展轨迹的改善无关。唯一有意义的发现表明，在研究期间，他汀类药物使用时间的延长与WOMAC身体功能评分的恶化有关(Beta=0.161，p=0.005)。结论在4年的研究期间，他汀类药物的使用与膝关节疼痛、功能或结构进展的改善无关。
Objectives Recently published research suggests that statins may have beneficial structural effects in persons with knee osteoarthritis (OA). The potential effects of statins on patient-reported knee pain and function have not been examined. We studied a large prospective community-based cohort of persons with knee OA to determine if statin usage was associated with changes in knee structure, pain and function trajectories.Methods Data were obtained from the Osteoarthritis Initiative using a subset of 2207 persons with radiographically suspected or confirmed knee OA. The changes in Western Ontario and McMaster Universities Arthritis Index (WOMAC) Pain and Physical Function scores, pain intensity and Kellgren-Lawrence radiographic grade over 4 years were examined. Data from persons were coded based on whether they were incident users of statins over the 4-year period. Outcome trajectories and probability of statin use were examined over the 4-year study period using parallel processing growth curve modelling. The analysis adjusted for potential confounders and determined if statin use predicted outcome trajectories.Results Statin users accounted for 6.7% of the sample in year 1 and 16.4% in year 4. Statin use was not associated with improvements in knee pain, function or structural progression trajectories. The only significant finding indicated that increased duration of statin use was associated with worsening in WOMAC Physical Function scores over the study period (beta = 0.161, p = 0.005).Conclusions Statin use was not associated with improvements in knee pain, function or structural progression over the 4-year study period.