Emerging roles of Fgf14 in behavioral control.
Emerging roles of Fgf14 in behavioral control.
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FGF14在行为控制中的新作用。
DOI：
10.1016/j.bbr.2018.08.034
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发表时间：
2019-01-01
影响因子：
2.7
通讯作者：
Tempia, Filippo
中科院分区：
文献类型：
--
作者：
Hoxha, Eriola;Marcinno, Andrea;Montarolo, Francesca;Masante, Linda;Balbo, Ilaria;Ravera, Francesco;Laezza, Fernanda;Tempia, Filippo
性障碍和攻击性是一个主要的社会问题。然而，控制这些行为的分子机制很大程度上是未知的。 FGF14 是一种控制神经元兴奋性和突触传递的细胞内蛋白，与神经系统和精神疾病有关。 Fgf14 缺失的小鼠对滥用药物的反应迟钝。通过行为测试，我们发现雄性 Fgf14 基因敲除小鼠的多种行为显着减少，包括攻击性和性行为。 Fgf14 基因敲除小鼠中，由自发主动性驱动的其他行为（如埋新物体、自发挖掘和攀爬）也有所减少。这些缺陷不能归因于活动水平的普遍下降，因为在旷场测试中，Fgf14 敲除小鼠具有与野生型相同的自发运动，并且饲养增加。我们的结果表明 Fgf14 对于保留一组行为很重要，并表明 Fgf14 对神经元功能的微调是控制此类行为的重要机制。
Sexual disturbances, and aggressivity are a major social problem. However, the molecular mechanisms involved in the control of these behaviors are largely unknown. FGF14, which is an intracellular protein controlling neuronal excitability and synaptic transmission, has been implied in neurologic and psychiatric disorders. Mice with Fgf14 deletion show blunted responses to drugs of abuse. By behavioral tests we show that male Fgf14 knockout mice have a marked reduction of several behaviors including aggressivity and sexual behavior. Other behaviors driven by spontaneous initiative like burying novel objects and spontaneous digging and climbing are also reduced in Fgf14 knockout mice. These deficits cannot be attributed to a generalized decrease of activity levels, because in the open field test Fgf14 knockout mice have the same spontaneous locomotion as wild types and increased rearing. Our results show that Fgf14 is important to preserve a set of behaviors and suggest that fine tuning of neuronal function by Fgf14 is an important mechanism of control for such behaviors.
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影响因子：
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