INDUCTION OF HAIR FOLLICLES BY EMBRYONIC DERMAL PAPILLAE
INDUCTION OF HAIR FOLLICLES BY EMBRYONIC DERMAL PAPILLAE
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DOI：
10.1111/1523-1747.ep12260492
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发表时间：
1970-01-01
影响因子：
6.5
通讯作者：
KOLLAR, EJ
中科院分区：
文献类型：
--
作者：
KOLLAR, EJ
从口鼻部、足背和足底面分离的胚胎上皮和中胚层组织的实验组合中检查了皮毛和触须毛囊的发育。通过冷胰蛋白酶消化分离组织后，将实验和对照外植体移植到同种成人眼的前房。当来自毛囊承载区域的中胚层组织与来自足板的无毛上皮结合时，毛囊和皮脂腺被诱导。眼内移植物发育完整协调。两个毛发区域之间的组织实验交换表明，来自吻部和背部的上皮细胞可以参与同源和异源的毛囊中胚层产生毛囊。这些数据提供了确凿的证据，在个体发育的皮毛和触须毛囊的毛乳头的诱导作用。
Pelage and vibrissal follicle development was examined in experimental combinations of embryonic epithelial and mesodermal tissues isolated from the snout, dorsum and plantar surfaces of the foot plate. Following separation of the tissues by cold tryptic digestion, experimental and control explants were grafted to the anterior chambers of homologous adult eyes. When mesodermal tissues from follicle-bearing areas are combined with glabrous epithelium from the foot plate, hair follicles and sebaceous glands are induced. Complete and harmonius development occurs in the intraocular grafts. Experimental exchanges of tissues between the two hair-bearing regions indicated that epithelium from the snout and dorsum can participate with homologous and heterologous follicle-bearing mesoderm to produce hair follicles. These data provide conclusive evidence for the inductive role of the dermal papilla during the ontogeny of pelage and vibrissae follicles.