The effect of donor age on human erythrocyte density distribution
The effect of donor age on human erythrocyte density distribution
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DOI：
10.1016/s0047-6374(97)01885-x
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发表时间：
1997-07-01
影响因子：
5.3
通讯作者：
Pinkofsky, HB
中科院分区：
文献类型：
--
作者：
Pinkofsky, HB
据报道，红细胞密度随着体内衰老而增加。梯度离心技术允许从全血中纯化不同密度的红细胞。随着献血者年龄的增加，全血的百分位数贡献也随之增加。同样，红细胞的高密度成分随着供体年龄的增加而减少。在本研究中，这些变化被调查并发现与供体年龄呈对数关系。其病因尚不清楚，但可能与老年人红细胞寿命缩短有关。(C) 1997爱思唯尔科学爱尔兰有限公司
Erythrocyte density has been reported to increase with in vivo aging. Gradient centrifugation techniques allow different density erythrocyte fractions to be purified from whole blood. As the donor age increases there is a concomitant increase in the percentile contribution of whole blood by a light density fraction. Similarly, a heavy density component of erythrocytes decreases with increasing donor age. In the present study these changes were investigated and found to exhibit a logarithmic relationship to donor age. The etiology of this is unknown but may be due to a decreased erythrocyte lifespan in older individuals. (C) 1997 Elsevier Science Ireland Ltd.