Facilitation and refractoriness of the electrically evoked compound action potential
Facilitation and refractoriness of the electrically evoked compound action potential
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DOI：
10.1016/j.heares.2017.09.001
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发表时间：
2017-11-01
期刊：
影响因子：
2.8
通讯作者：
Killian, Matthijs
中科院分区：
文献类型：
--
作者：
Hey, Matthias;Mueller-Deile, Joachim;Killian, Matthijs
在这项研究中，我们的目标是解决在非常短的脉冲间隔的促进和不应期的贡献。测量耳蜗植入（CI）用户在低于300 μ s的脉冲间隔时听神经的电诱发复合动作电位（ECAP）的不应特性受易化和恢复效应的影响。使用掩蔽脉冲记录ECAP，该掩蔽脉冲具有相对于探测脉冲水平的宽范围的电流水平，对于三个阈上探测水平和从13到200 μ s的脉冲间隔。本文采用掩蔽反应提取伪影消除法测定了21例脑梗塞患者的诱发电位，分析时不以刺激电流作为绝对值，而是与患者的ECAP阈值相联系。这使得一个更一般的方法来描述促进作为一个探针水平独立的影响。最大的促进作用，发现所有测试的脉冲间的间隔在掩蔽水平附近的病人的个人ECAP阈值，独立于探头水平。对于短的脉冲间间隔，增加N1P1振幅被测量为阈下掩蔽水平下降到120 CL以下的患者的个人ECAP阈值相比，重建states.ECAP记录与脉冲间间隔高达200 μ s的促进和恢复的影响。易化效应在ECAP阈值或低于ECAP阈值的掩蔽水平下最明显，而恢复效应随着高于ECAP阈值的掩蔽水平的增加而增加。掩蔽能级在ECAP阈值附近的ECAP振幅的局部极大值可以用最大易化和最小不应度的相互影响来解释。(C)2017作者由爱思唯尔公司出版
In this study we aim to resolve the contributions of facilitation and refractoriness at very short pulse intervals. Measurements of the refractory properties of the electrically evoked compound action potential (ECAP) of the auditory nerve in cochlear implant (CI) users at inter pulse intervals below 300 mu s are influenced by facilitation and recovery effects. ECAPs were recorded using masker pulses with a wide range of current levels relative to the probe pulse levels, for three suprathreshold probe levels and pulse intervals from 13 to 200 mu s. Evoked potentials were measured for 21 CI patients by using the masked response extraction artifact cancellation procedure.During analysis of the measurements the stimulation current was not used as absolute value, but in relation to the patient's individual ECAP threshold. This enabled a more general approach to describe facilitation as a probe level independent effect. Maximum facilitation was found for all tested inter pulse intervals at masker levels near patient's individual ECAP threshold, independent from probe level. For short inter pulse intervals an increased N1P1 amplitude was measured for subthreshold masker levels down to 120 CL below patient's individual ECAP threshold in contrast to the recreated state.ECAPs recorded with inter pulse intervals up to 200 mu s are influenced by facilitation and recovery. Facilitation effects are most pronounced for masker levels at or below ECAP threshold, while recovery effects increase with higher masker levels above ECAP threshold. The local maximum of the ECAP amplitude for masker levels around ECAP threshold can be explained by the mutual influence of maximum facilitation and minimal refractoriness. (C) 2017 The Authors. Published by Elsevier B.V.