Piecewise nonlinear mixed-effects models for modeling cardiac function and assessing treatment effects.
Piecewise nonlinear mixed-effects models for modeling cardiac function and assessing treatment effects.
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DOI：
10.1016/j.cmpb.2012.11.007
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发表时间：
2013-06
影响因子：
6.1
通讯作者：
Kong M
中科院分区：
文献类型：
--
作者：
Jang H;Conklin DJ;Kong M
Mixed-effects model is an efficient tool for analyzing longitudinal data. The random effects in a mixed-effects model can be used to capture the correlations among repeated measurements within a subject. Mixed effects model can be used to describe individual response profile as well as population response profile. In this manuscript, we apply mixed-effects models to the repeated measurements of cardiac function variables including heart rate, coronary flow, and left ventricle developed pressure (LVDP) in the isolated, Langendorff-perfused hearts of glutathione s-transferase P1/P2 (GSTP) gene knockout and wild-type mice. Cardiac function was measured before and during ischemia/reperfusion injury in these hearts. To describe the dynamics of each cardiac function variable during the entire experiment, we developed piecewise nonlinear mixed-effects models and a change point nonlinear mixed effect model. These models can be used to examine how cardiac function variables were altered by ischemia/reperfusion-induced injury and to compare the cardiac function variable between genetically engineered (null or transgenic) mice and wild-type mice. Hypothesis tests were constructed to evaluate the impact of deletion of GSTP gene for different cardiac function variables. These findings provide a new application for mixed-effects models in physiological and pharmacological studies of the isolated Langendorff-perfused heart.
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影响因子：
37.8
作者：
West MB;Rokosh G;Obal D;Velayutham M;Xuan YT;Hill BG;Keith RJ;Schrader J;Guo Y;Conklin DJ;Prabhu SD;Zweier JL;Bolli R;Bhatnagar A
通讯作者：
Bhatnagar A
影响因子：
6.8
作者：
AKAIKE, H
通讯作者：
AKAIKE, H
影响因子：
7
作者：
Cudeck, R;Klebe, KJ
通讯作者：
Klebe, KJ
影响因子：
1.9
作者：
LINDSTROM, MJ;BATES, DM
通讯作者：
BATES, DM
DOI：
10.1073/pnas.95.9.5275
发表时间：
1998-04-28
影响因子：
11.1
作者：
Henderson, CJ;Smith, AG;Wolf, CR
通讯作者：
Wolf, CR