Single-Molecule Analysis with Solid-State Nanopores
Single-Molecule Analysis with Solid-State Nanopores
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DOI：
10.1146/annurev-anchem-061417-125903
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发表时间：
2019-01-01
期刊：
影响因子：
--
通讯作者：
Albrecht, Tim
中科院分区：
文献类型：
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作者：
Albrecht, Tim
固态纳米孔和纳米移液管是一类令人兴奋的单分子传感器，在过去二十年中发展迅速。它们提供了一个平台，用于测试纳米级随机性和传输的基本概念，用于研究单分子生物物理学，并且越来越多地用于新的分析应用和生物医学传感。这篇评论涵盖了支撑传感器操作和运输的一些基本方面，同时，它的目的是把这些作为一种分析技术。报告重点介绍了新的和最近的事态发展，并讨论了今后的一些挑战。
Solid-state nanopores and nanopipettes are an exciting class of single-molecule sensors that has grown enormously over the last two decades. They offer a platform for testing fundamental concepts of stochasticity and transport at the nanoscale, for studying single-molecule biophysics and, increasingly, also for new analytical applications and in biomedical sensing. This review covers some fundamental aspects underpinning sensor operation and transport and, at the same time, it aims to put these into context as an analytical technique. It highlights new and recent developments and discusses some of the challenges lying ahead.