Fullerene Covalent Passivation of Black Phosphorus Nanosheets toward Enhanced Near-Infrared-II Photothermal Therapy
Fullerene Covalent Passivation of Black Phosphorus Nanosheets toward Enhanced Near-Infrared-II Photothermal Therapy
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DOI：
10.1021/acsami.3c01074
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发表时间：
2023-04-24
影响因子：
9.5
通讯作者：
Yang, Shangfeng
中科院分区：
文献类型：
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作者：
Xie, Chang;Wang, Li;Yang, Shangfeng
由近红外II（NIR-II，1000-1700 nm）光触发的光热治疗（PTT）是一种潜在的肿瘤治疗技术，具有更深的组织穿透能力和比NIR-I（750-1000 nm）biowindow更高的皮肤允许激光功率密度。黑磷（BP）具有良好的生物相容性和生物可降解性，在PTT中具有良好的应用前景，但存在环境稳定性差、光热转化效率低等问题，在近红外-Ⅱ PTT中的应用报道较少。在此，我们开发了新型富勒烯共价修饰的少层BP纳米片（BPNS），通过简单的一步酯化过程（简称BP酯-C60），由于具有高稳定性的疏水C60和磷原子上的孤电子对的键合，BPNS的环境稳定性显着增强。然后将BP-酯-C60作为光敏剂应用于NIR-II PTT中，提供比原始BPNS高得多的PCE。在1064 nm NIR-II激光照射下，体外和体内抗肿瘤研究表明，BP-酯-C60相对于原始BPNS表现出显著增强的PTT功效和相当大的生物安全性。这是解释的近红外光吸收的提升上的调制的能带能级产生的分子内电子转移从BPNS到C60。
Photothermal therapy (PTT) triggered by near-infrared-II (NIR-II, 1000-1700 nm) light is developed as a potential tumor therapy technique with deeper tissue penetration capacity and higher allowable laser power density of the skin than NIR-I (750-1000 nm) biowindow. Black phosphorus (BP) with excellent biocompatibility and favorable biodegradability demon-strates promising applications in PTT but suffers from low ambient stability and limited photothermal conversion efficiency (PCE), and utilization of BP in NIR-II PTT is scarcely reported. Herein, we develop novel fullerene covalently modified few-layer BP nanosheets (BPNSs) with similar to 9-layer thickness through an easy one-step esterification process (abbreviated BP-ester-C60), bringing about the dramatically enhanced ambient stability of BPNSs due to bonding of the hydrophobic C60 with high stability and the lone electron pair on the phosphorus atom. BP-ester-C60 is then applied as a photosensitizer in NIR-II PTT, delivering a much higher PCE than the pristine BPNSs. Under 1064 nm NIR-II laser irradiation, in vitro and in vivo antitumor studies reveal that BP-ester-C60 exhibits dramatically enhanced PTT efficacy with considerable biosafety relative to the pristine BPNSs. This is interpreted by the boost of NIR light absorption on account of the modulation of the band energy level resulting from intramolecular electron transfer from BPNSs to C60.