TRANSFAC®:: transcriptional regulation, from patterns to profiles
TRANSFAC®:: transcriptional regulation, from patterns to profiles
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DOI：
10.1093/nar/gkg108
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发表时间：
2003-01-01
影响因子：
14.9
通讯作者：
Wingender, E
中科院分区：
文献类型：
--
作者：
Matys, V;Fricke, E;Wingender, E
关于真核转录调控的TRANSFAC（R）数据库包括关于转录因子、其靶基因和调控结合位点的数据，该数据库在条目数量以及所收集数据的范围和结构方面都得到了扩展和进一步发展。使用关于解剖结构和发育阶段的CYTOMER（R）数据库，已经为来自人类和小鼠的转录因子引入了表达模式的结构化字段。Match（TM）是一种基于矩阵搜索转录因子结合位点的工具，其功能已得到增强。例如，该程序现在沿着了许多组织（或状态）特定的轮廓，并且可以用MatchTM轮廓仪创建和修改新的轮廓。GENE表得到了扩展并获得了重要性，现在包含LocusLink，RefSeq和OMIM的链接。此外，一方面因子和靶基因之间的（直接）联系，另一方面基因和编码因子之间的介绍。TRANSFAC 1的公开发布可在http：/ / www.基因调控com.对于酵母，包括最新数据的额外版本作为TRANSFAC 1 Saccharomyces Module（TSM）在http：/ / transfac上单独提供。gbf。de. CYTOMER（R）的免费下载版本可在http：/ / www.生物基de：8080/ index. HTML.
The TRANSFAC(R) database on eukaryotic transcriptional regulation, comprising data on transcription factors, their target genes and regulatory binding sites, has been extended and further developed, both in number of entries and in the scope and structure of the collected data. Structured fields for expression patterns have been introduced for transcription factor from human and mouse, using the CYTOMER(R) database on anatomical structures and developmental stages. The functionality of Match(TM), a tool for matrix-based search of transcription factor binding sites, has been enhanced. For instance, the program now comes along with a number of tissue( or state-) specific profiles and new profiles can be created and modified with Match(TM) Profiler. The GENE table was extended and gained in importance, containing amongst others links to LocusLink, RefSeq and OMIM now. Further, ( direct) links between factor and target gene on one hand and between gene and encoded factor on the other hand were introduced. The TRANSFAC 1 public release is available at http: / / www. gene-regulation. com. For yeast an additional release including the latest data was made available separately as TRANSFAC 1 Saccharomyces Module (TSM) at http: / / transfac. gbf. de. For CYTOMER(R) free download versions are available at http: / / www. biobase. de: 8080/ index. html.