Longitudinal Follow-Up of Gross Motor Function in Children with Congenital Zika Virus Syndrome from a Cohort in Rio de Janeiro, Brazil.
Longitudinal Follow-Up of Gross Motor Function in Children with Congenital Zika Virus Syndrome from a Cohort in Rio de Janeiro, Brazil.
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DOI：
10.3390/v14061173
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发表时间：
2022-05-28
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了解先天性寨卡综合征（CZS）如何纵向影响儿童的运动发育对于指导管理非常重要。本研究的目的是描述在里约热内卢医院的CZS儿童粗大运动功能的演变。在一项前瞻性队列研究中随访的无关节弯曲或其他先天性骨关节畸形的CZS儿童中，使用粗大运动功能分类系统（GMFCS）和粗大运动功能测量测试（GMFM-88）在两个时间点评价运动表现。在74名儿童中，基线评估时，中位年龄为13（8-24）个月，随访时为28（24-48）个月。根据第二个时间点的GMFCS，6名儿童被归类为轻度，11名为中度，57名为重度。在GMFM-88评估中，重度组儿童的基线评估中位评分为10.05，随访评分为12.40，中度组的中位评分分别为25.60和29.60，轻度组的中位评分分别为82.60和91.00。虽然观察到一个小的发育改善，运动障碍的儿童主要是符合严重的脑瘫。基线运动功能评估可预测预后。
Knowledge of how congenital Zika syndrome (CZS) impacts motor development of children longitudinally is important to guide management. The objective of the present study was to describe the evolution of gross motor function in children with CZS in a Rio de Janeiro hospital. In children with CZS without arthrogryposis or other congenital osteoarticular malformations who were followed in a prospective cohort study, motor performance was evaluated at two timepoints using the Gross Motor Function Classification System (GMFCS) and the Gross Motor Function Measurement test (GMFM-88). Among 74 children, at the baseline evaluation, the median age was 13 (8–24) months, and on follow-up, 28 (24–48) months. According to GMFCS at the second timepoint, 6 children were classified as mild, 11 as moderate, and 57 as severe. In the GMFM-88 assessment, children in the severe group had a median score of 10.05 in the baseline evaluation and a follow-up score of 12.40, the moderate group had median scores of 25.60 and 29.60, and the mild group had median scores of 82.60 and 91.00, respectively. Although a small developmental improvement was observed, the motor impairment of children was mainly consistent with severe cerebral palsy. Baseline motor function assessments were predictive of prognosis.
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DOI：
10.3390/ijerph15061107
发表时间：
2018-06-01
影响因子：
--
作者：
Confessor Ferreira, Haryelle Naryma;Schiariti, Veronica;Longo, Egmar
通讯作者：
Longo, Egmar
影响因子：
168.9
作者：
Franca, Giovanny V. A.;Schuler-Faccini, Lavinia;Victora, Cesar G.
通讯作者：
Victora, Cesar G.
影响因子：
3.5
作者：
Aragao, M. F. V. V.;Holanda, A. C.;Costello, A.
通讯作者：
Costello, A.
影响因子：
120.7
作者：
Rosenbaum, PL;Walter, SD;Galuppi, BE
通讯作者：
Galuppi, BE
影响因子：
1.9
作者：
de Carvalho, Alessandra Lemos;Ventura, Paloma;Lucena, Rita
通讯作者：
Lucena, Rita