CFD simulation of solid-liquid suspension characteristics in stirred tank reactor
CFD simulation of solid-liquid suspension characteristics in stirred tank reactor
复制标题
搅拌釜反应器固液悬浮特性的CFD模拟
DOI：
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发表时间：
2009
期刊：
影响因子：
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通讯作者：
Yin Jian
中科院分区：
文献类型：
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作者：
Yin Jian
在免疫吸附血液净化材料蛋白A的制备中，搅拌釜式生物反应器的优化设计和放大是工业化过程的关键环节。本文采用标准κ-e湍流模型和多参考系方法，对搅拌釜反应器中固体催化剂加入琼脂糖凝胶溶液时固液混合悬浮特性进行了数值模拟。通过对DT、PBTD 45和PBTU 45三种桨的固相悬浮性能的研究，预测了悬浮时的转速，并与Zwietering关联式进行了比较。通过计算流体力学模拟，为优化制备血液净化材料的生物反应器提供参考指导。
In the preparation of the blood purification material protein A immunoadsorption, the optimization design and scale-up of the stirred tank bioreactor are the key links of the industrial process. In this paper, standard κ-e turbulence model and multi-reference frame method are applied to simulate the mixing and suspending characteristics of solid-liquid when adding solid catalyst to sepharose solution in the stirred tank reactor. By the researches on the solid phase suspended performance of three types of impellers, which are DT, PBTD45 and PBTU45, just-suspended impeller speeds are predicted, and the results are compared with the Zwietering correlation. Through the computational fluid dynamics simulations, the reference guidance is provided to optimize bioreactor for preparing the blood purification material.