Estimation of absolute myocardial blood flow during first-pass MR perfusion imaging using a dual-bolus injection technique: Comparison to single-bolus injection method
Estimation of absolute myocardial blood flow during first-pass MR perfusion imaging using a dual-bolus injection technique: Comparison to single-bolus injection method
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DOI：
10.1002/jmri.21383
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发表时间：
2008-06-01
影响因子：
4.4
通讯作者：
Arai, Andrew E.
中科院分区：
文献类型：
--
作者：
Christian, Timothy F.;Aletras, Anthony H.;Arai, Andrew E.
目的：比较双推注与单推注定量首过磁共振心肌灌注成像对绝对心肌血流量（MBF）的估计。材料和方法：狗有局部充血。左冠状动脉前降支 (LAD) 中的 MBF（冠状动脉内腺苷）。动物 (n = 6) 进行了连续单次和双次推注灌注研究，并用微球测定了绝对 MBF。使用饱和度恢复梯度回波序列进行灌注成像。绝对 MBF 通过费米函数反卷积计算，并与同一感兴趣区域 (ROT) 中的透壁、心内膜和心外膜微球值进行比较。结果：双团注灌注图像的信号和对比度显着更高。对于双推注方法，微球与 MBF 的相关性为 r = 0.94，对于单推注方法，r = 0.91。两种技术的透壁节段的对照区或充血区的 MRI 和微球 MBF 值之间没有显着差异。当减少 ROT 来定义心内膜和心外膜区时，单次团注 MR 首过成像显着高估了 MBF，并且与双团注灌注相比，与微球相比具有显着更大的绝对误差。 结论：单次团注和双团注灌注方法均与 MBF 密切相关，但双团注图像的信号和对比度更大。对于信号减少的较小的非透壁 ROI，双团注方法似乎可以提供稍微更准确的结果。
Purpose: To compare the dual-bolus to single-bolus quantitative first-pass magnetic resonance myocardial perfusion imaging for estimation of absolute myocardial blood flow (MBF).Materials and Methods: Dogs had local hyperemia. of MBF in the left anterior descending (LAD) coronary artery (intra-coronary adenosine). Animals (n = 6) had sequential single-and dual-bolus perfusion studies with microsphere determination of absolute MBF. Perfusion imaging was performed using a saturation-recovery gradient-echo sequence. Absolute MBF was by Fermi function deconvolution and compared to transmural, endocardial, and epicardial microsphere values in the same region of interest (ROT).Results: Signal and contrast were significantly higher for the dual-bolus perfusion images. The correlation with MBF by microspheres was r = 0.94 for the dual-bolus method and r = 0.91 for the single-bolus method. There was no significant difference between MRI and microsphere MBF values for control or hyperemic zones for transmural segments for either technique. When the ROT was reduced to define endocardial and epicardial zones, single-bolus MR first-pass imaging significantly overestimated MBF and had a significantly larger absolute error vs. microspheres when compared to dual-bolus perfusion.Conclusion: Both single-bolus and dual-bolus perfusion methods correlate closely with MBF but the signal and contrast of the dual-bolus images are greater. With smaller nontransmural ROIs where signal is reduced, the dual-bolus method appeared to provide slightly more accurate results.