Bisacodyl and high-amplitude-propagating colonic contractions in children
Bisacodyl and high-amplitude-propagating colonic contractions in children
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DOI：
10.1097/00005176-199810000-00006
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发表时间：
1998-10-01
影响因子：
2.9
通讯作者：
Hyman, PE
中科院分区：
文献类型：
--
作者：
Hamid, SA;Di Lorenzo, C;Hyman, PE
背景：这些研究的目的是确定在儿童结肠测压研究中刺激高振幅扩张性收缩的适宜性。方法：将水灌注测压导管插入患儿右结肠进行排便障碍相关评估。结肠运动在3小时的测试过程中测量：禁食1小时，饭后1小时，服用刺激剂后30分钟。结果：比沙可啶在诱导高振幅扩张性收缩方面优于埃洛芬铵。bisacodyl诱导的高振幅传播收缩与自然发生的高振幅传播收缩在振幅、持续时间、传播速度、起源和消失位置上相似。除起效延迟10分钟外，直肠内使用比沙可达的效果与直肠内使用比沙可达相似。所有28名儿童（22名自发性高振幅扩张性收缩）均无神经肌肉疾病证据，9名结肠神经肌肉疾病儿童中有2名无自发性高振幅扩张性收缩。结论：bisacodyl诱导的高振幅扩张性收缩在数量和质量上与自然发生的高振幅扩张性收缩相似。在特定的情况下，如接受全肠外营养或限制液体摄入的儿童，可以使用比沙代缩短诊断性结肠测压时间，而不是等待自发性高振幅扩张性收缩。
Background: The purpose of these studies was to determine the suitability of bisacodyl for stimulating high-amplitude-propagating contractions in pediatric studies of colonic manometry.Methods: Water-perfused manometry catheters were inserted into the right colon of children referred for evaluations related to defecation disorders. Colonic motility was measured in a 3-hour test session: an hour fasting, an hour after a meal, and 30 minutes after administration of a provocative agent.Results: Bisacodyl was superior to edrophonium as a stimulant for inducing high-amplitude-propagating contractions. Bisacodyl-induced high-amplitude-propagating contractions were similar in amplitude, duration, propagation velocity, and sites of origin and extinction to naturally occurring high-amplitude-propagating contractions. The effect of intrarectal bisacodyl was similar to that of intracecal bisacodyl, except for a delay of 10 minutes in onset. Bisacodyl induced high-amplitude-propagating contractions in all 28 children (22 with spontaneous high-amplitude-propagating contractions) without evidence of neuromuscular disease and in 2 of 9 children with a colonic neuromuscular disorder and no spontaneous high-amplitude-propagating contractions.Conclusions: Bisacodyl-induced high-amplitude-propagating contractions were quantitatively and qualitatively similar to naturally occurring high-amplitude-propagating contractions. In selected cases, such as in children receiving total parenteral nutrition or restricted fluid intake, it may be possible to shorten diagnostic colonic manometry using bisacodyl rather than waiting for spontaneous high-amplitude-propagating contractions.