ASYMMETRICAL LIPID BILAYER STRUCTURE FOR BIOLOGICAL-MEMBRANES
ASYMMETRICAL LIPID BILAYER STRUCTURE FOR BIOLOGICAL-MEMBRANES
复制标题
DOI：
10.1038/newbio236011a0
复制
发表时间：
1972-01-01
期刊：
影响因子：
--
通讯作者：
BRETSCHER, MS
中科院分区：
文献类型：
--
作者：
BRETSCHER, MS
人们普遍认为，细胞膜的基质是磷脂分子的双分子叶，其中磷脂定向，使其极头位于双层的外表面，与水环境接触，三明治的内部由疏水脂链1-5组成。在这种基本结构中，通常插入蛋白质胆固醇、糖脂和其他分子，以赋予双层适合于特定膜的功能性质。
IT is generally accepted that the matrix of cellular membranes is a bimolecular leaflet of phospholipid molecules in which the phospholipids are oriented so that their polar heads reside on the outer surfaces of the bilayer, in contact with the aqueous environment, the interior of the sandwich being composed of hydrophobic lipid chains1–5. To this basic structure proteins cholesterol, glycolipids and other molecules are usually inserted in such a way as to confer on the bilayer the functional properties appropriate for the particular membrane.