High temporal versus high spatial resolution in MR quantitative pulmonary perfusion imaging of two-year old children after congenital diaphragmatic hernia repair
High temporal versus high spatial resolution in MR quantitative pulmonary perfusion imaging of two-year old children after congenital diaphragmatic hernia repair
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DOI：
10.1007/s00330-014-3304-9
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发表时间：
2014-10-01
影响因子：
5.9
通讯作者：
Neff, K. W.
中科院分区：
文献类型：
--
作者：
Weidner, M.;Zoellner, F. G.;Neff, K. W.
先天性腹股沟疝（CDH）导致肺发育不全。使用动态对比增强（DCE）MR成像，可以量化肺灌注。由于MR灌注值依赖于时间分辨率，我们比较了两种方案，以研究CDH后同侧肺灌注是否受损，是否存在方案依赖性差异，以及哪种方案是首选。（3.0 s;体素：1.25 mm（3））和方案B（n = 18）在高时间分辨率（1.5 s;体素：2 mm（3））上。肺血流量（PBF）、肺血容量（PBV）、平均通过时间（MTT）和峰值对比噪声比（PCNR）定量。同侧PBF减少，同侧PBF为45 +/- 26 ml/100 ml/min，对侧PBF为63 +/- 28 ml/100 ml/min（p = 0.0016）;对于方案B，侧差异相当（同侧PBF = 62 +/- 24 vs.对侧PBF = 85 +/- 30 ml/100 ml/min; p = 0.0034）。方案B的PCNR更高（30 +/- 18 vs. 20 +/- 9; p = 0.0294）。与方案A相比，方案B显示出更高的PBF值（p总是< 0.05）。更高的时间分辨率和增加的体素大小显示PCNR的增益，并导致更高的灌注值。因此，首选方案B。a欧分定量肺灌注参数取决于时间和空间分辨率。a欧分CDH中肺灌注的减少可以用不同的MR方案测量。a欧分时间分辨率为1.5 s，空间分辨率为2 mm（3）是合适的。
Congenital diaphragmatic hernia (CDH) leads to lung hypoplasia. Using dynamic contrast-enhanced (DCE) MR imaging, lung perfusion can be quantified. As MR perfusion values depend on temporal resolution, we compared two protocols to investigate whether ipsilateral lung perfusion is impaired after CDH, whether there are protocol-dependent differences, and which protocol is preferred.DCE-MRI was performed in 36 2-year old children after CDH on a 3 T MRI system; protocol A (n = 18) based on a high spatial (3.0 s; voxel: 1.25 mm(3)) and protocol B (n = 18) on a high temporal resolution (1.5 s; voxel: 2 mm(3)). Pulmonary blood flow (PBF), pulmonary blood volume (PBV), mean transit time (MTT), and peak-contrast-to-noise-ratio (PCNR) were quantified.PBF was reduced ipsilaterally, with ipsilateral PBF of 45 +/- 26 ml/100 ml/min to contralateral PBF of 63 +/- 28 ml/100 ml/min (p = 0.0016) for protocol A; and for protocol B, side differences were equivalent (ipsilateral PBF = 62 +/- 24 vs. contralateral PBF = 85 +/- 30 ml/100 ml/min; p = 0.0034). PCNR was higher for protocol B (30 +/- 18 vs. 20 +/- 9; p = 0.0294). Protocol B showed higher values of PBF in comparison to protocol A (p always < 0.05).Ipsilateral lung perfusion is reduced in 2-year old children following CDH repair. Higher temporal resolution and increased voxel size show a gain in PCNR and lead to higher perfusion values. Protocol B is therefore preferred.aEuro cent Quantitative lung perfusion parameters depend on temporal and spatial resolution.aEuro cent Reduction of lung perfusion in CDH can be measured with different MR protocols.aEuro cent Temporal resolution of 1.5 s with spatial resolution of 2 mm (3) is suitable.