AP-1 subunits: quarrel and harmony among siblings
AP-1 subunits: quarrel and harmony among siblings
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DOI：
10.1242/jcs.01589
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发表时间：
2004-12-01
影响因子：
4
通讯作者：
Schorpp-Kistner, M
中科院分区：
文献类型：
--
作者：
Hess, J;Angel, P;Schorpp-Kistner, M
AP - 1转录因子主要由Jun、Fos和ATF蛋白二聚体组成。它介导基因调控以应对众多生理和病理刺激，包括细胞因子、生长因子、应激信号、细菌和病毒感染以及致癌刺激。对转基因小鼠和细胞的研究强调了AP - 1在参与正常发育或导致癌症的肿瘤性转化的多种细胞事件中的关键作用。然而，新出现的证据表明，AP - 1对细胞命运决定的作用关键取决于AP - 1亚基的相对丰度、AP - 1二聚体的组成、刺激的性质、细胞类型和细胞环境。因此，应在同时响应的信号通路和其他核因子的复杂动态网络背景下考虑AP - 1对增殖、分化、凋亡和转化等过程的调控。
The AP-1 transcription factor is mainly composed of Jun, Fos and ATF protein dimers. It mediates gene regulation in response to a plethora of physiological and pathological stimuli, including cytokines, growth factors, stress signals, bacterial and viral infections, as well as oncogenic stimuli. Studies in genetically modified mice and cells have highlighted a crucial role for AP-1 in a variety of cellular events involved in normal development or neoplastic transformation causing cancer. However, emerging evidence indicates that the contribution of AP-1 to determination of cell fates critically depends on the relative abundance of AP-1 subunits, the composition of AP-1 dimers, the quality of stimulus, the cell type and the cellular environment. Therefore, AP-1-mediated regulation of processes such as proliferation, differentiation, apoptosis and transformation should be considered within the context of a complex dynamic network of signalling pathways and other nuclear factors that respond simultaneously.