Maternal illness and drug/medication use during the period surrounding pregnancy and risk of childhood leukemia among offspring
Maternal illness and drug/medication use during the period surrounding pregnancy and risk of childhood leukemia among offspring
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DOI：
10.1093/aje/kwj336
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发表时间：
2007-01-01
影响因子：
5
通讯作者：
Buffler, Patricia A.
中科院分区：
文献类型：
--
作者：
Kwan, Marilyn L.;Metayer, Catherine;Buffler, Patricia A.
怀孕期间的母亲疾病和药物/药物使用（处方、非处方和非法）可能与儿童白血病风险有关。使用北加州儿童白血病研究的数据（1995-2002）对这些问题进行了评估。作者选择了365名15岁以下的儿童，他们被诊断患有白血病，并在年龄、性别、西班牙裔和母亲种族方面与他们相匹配。通过对生母的访谈，获得孕前至母乳喂养期间的孕产妇疾病和药物使用情况，并采用条件logistic回归进行分析。母亲有流感/肺炎病史与后代患急性淋巴细胞白血病（ALL）的风险增加有统计学意义相关(优势比（OR) = 1.89, 95%可信区间（CI）： 1.24, 2.89），但普通ALL的风险不显著（OR = 1.41, 95% CI: 0.75, 2.63）。在性传播疾病史中也发现了类似的风险增加模式。使用铁补充剂表明ALL风险降低（OR = 0.67, 95% CI: 0.47, 0.94）。观察到在怀孕期间报告有流感/肺炎和性传播疾病病史的母亲的孩子患白血病的风险增加，这表明母体感染可能导致白血病的病因。此外，母亲铁补充剂的使用可能对儿童白血病有保护作用。
Maternal illness and drug/medication use (prescription, over-the-counter, and illicit) during pregnancy might be related to childhood leukemia risk. These issues were evaluated using data (1995-2002) from the Northern California Childhood Leukemia Study. The authors selected 365 children under age 15 years who had been diagnosed with incident leukemia and birth certificate controls who were matched to them on age, sex, Hispanic ethnicity, and maternal race. Data on maternal illnesses and drug use from before pregnancy through breastfeeding were obtained by interview with the biologic mother and were analyzed by conditional logistic regression. Maternal history of influenza/pneumonia was associated with a statistically significant increased risk of acute lymphoblastic leukemia (ALL) in the offspring (odds ratio (OR) = 1.89, 95% confidence interval (CI): 1.24, 2.89), although the risk was nonsignificant for common ALL (OR = 1.41, 95% CI: 0.75, 2.63). A similar pattern of increased risk was found for history of sexually transmitted disease. Use of iron supplements was indicative of decreased ALL risk (OR = 0.67, 95% CI: 0.47, 0.94). Observing an increased risk of leukemia in children of mothers reporting a history of influenza/pneumonia and sexually transmitted disease around the time of pregnancy suggests that maternal infection might contribute to the etiology of leukemia. Furthermore, maternal iron supplement use may be protective against childhood leukemia.