Effects of highly purified eicosapentaenoic acid and docosahexaenoic acid on hemodynamics in humans
Effects of highly purified eicosapentaenoic acid and docosahexaenoic acid on hemodynamics in humans
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DOI：
10.1093/ajcn/68.1.52
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发表时间：
1998-07-01
影响因子：
7.1
通讯作者：
Myhre, ESP
中科院分区：
文献类型：
--
作者：
Grimsgaard, S;Bonaa, KH;Myhre, ESP
尚未在人体中评价高纯度二十碳五烯酸（EPA，20：5 n-3）和二十二碳六烯酸（DHA，22：6 n-3）的血液动力学效应。因此，我们进行了一项随机、双盲、平行设计的干预研究，以评估EPA和DHA对血压、心率和心脏力学的可能单独影响。年龄在36-56岁之间的健康、不吸烟男性（n = 224）被随机分配到4 g/d的DHA或EPA乙酯浓缩物或4 g玉米油/d（对照）的膳食补充剂组。基线平均血压为122/77 mm Hg，与血清磷脂饱和脂肪酸浓度呈正相关。血压在干预期间没有变化，基线时的平均心率为63.4次/分; DHA组降低2.2次/分（与对照组相比P = 0.006），EPA组增加1.9次/分（与对照组相比P = 0.04），对照组几乎保持不变。在汇总分析中，心率的变化与基线心率无关，与血清磷脂DHA和二十二碳五烯酸（22：5 n-3）浓度的变化相关。超声心动图显示，与玉米油组相比，52名男性的子样本中，海洋石油组的左心室舒张期充盈改善（P = 0.02）。相反，饱和脂肪酸血浆浓度的增加与舒张期充盈延迟相关。我们的结论是，饮食中的DHA和EPA影响心率和血浆磷脂的脂肪酸组成可能会影响人类的心脏力学。
The hemodynamic effects of highly purified eicosapentaenoic acid (EPA, 20:5n-3) and docosahexaenoic acid (DHA, 22:6n-3) have not been evaluated in humans. We therefore conducted a randomized, double-blind, parallel-design intervention study to assess possible separate effects of EPA and DHA on blood pressure, heart rate, and cardiac mechanics. Healthy, nonsmoking men aged 36-56 y (n = 224) were randomly assigned to dietary supplementation with 4 g/d of ethyl ester concentrates of DHA or EPA or 4 g corn oil/d (control). Mean blood pressure at baseline was 122/77 mm Hg and was positively associated with concentrations of serum phospholipid saturated fatty acids. Blood pressure did not change during the intervention, Mean heart rate at baseline was 63.4 beats/min; it decreased 2.2 beats/min in the DHA group (P = 0.006 compared with control), increased 1.9 beats/min in the EPA group (P = 0.04 compared with control), and remained practically unchanged in the control group. In a pooled analysis, changes in heart rate were independent of baseline heart rate and were associated with changes in concentrations of serum phospholipid DHA and docosapentaenoic acid (22:5n-3). Echocardiography in a subsample of 52 men showed improved left ventricular diastolic filling in the marine oil groups compared with the corn oil group (P = 0.02), In contrast, an increase in plasma concentrations of saturated fatty acids was associated with delayed diastolic filling. We conclude that dietary DHA and EPA influence heart rate and that the fatty acid composition of plasma phospholipids may affect cardiac mechanics in humans.