Phosphate sensing.
Phosphate sensing.
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DOI：
10.1053/j.ackd.2011.01.004
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发表时间：
2011-03
影响因子：
2.9
通讯作者：
Jüppner H
中科院分区：
文献类型：
--
作者：
Bergwitz C;Jüppner H
人体磷酸盐稳态受肠道对饮食中磷酸盐的吸收、通过骨吸收释放磷酸盐和肾脏磷酸盐排泄水平的调节，并涉及甲状旁腺激素（PTH）、1,25-二羟基维生素D （1,25-(OH)2-D）和成纤维细胞生长因子23 （FGF23）的作用，以维持循环磷酸盐水平在一个狭窄的正常范围内，这对许多细胞功能、组织生长和骨矿化至关重要。原核生物和单细胞真核生物，如细菌和酵母，通过位于其质膜上的多蛋白复合物“感知”周围的磷酸盐，该复合物调节对磷酸盐摄取和代谢（磷酸途径）重要的基因的表达。仅基于氨基酸序列保守的数据库搜索无法识别细菌和酵母磷酸盐传感器的后生动物同源物。因此，对于人类和其他后生动物细胞如何感知无机磷酸盐来调节磷酸盐对细胞代谢的影响（“代谢”感知）或通过反馈系统调节细胞外磷酸盐水平（“内分泌”感知），我们知之甚少。“代谢”和“内分泌”传感器是否使用相同或不同的信号转导级联尚不清楚。本章将回顾细菌和酵母的磷酸盐传感器，然后讨论目前已知的磷酸盐在多细胞生物和人类中的代谢和内分泌作用。
Human phosphate homeostasis is regulated at the level of intestinal absorption of phosphate from the diet, release of phosphate through bone resorption, and renal phosphate excretion and involves the actions of parathyroid hormone (PTH), 1,25-dihydroxy-vitamin D (1,25-(OH)2-D), and fibroblast growth factor 23 (FGF23) to maintain circulating phosphate levels within a narrow normal range, which is essential for numerous cellular functions, for the growth of tissues and for bone mineralization. Prokaryotic and single cellular eukaryotic organisms such as bacteria and yeast “sense” ambient phosphate with a multi-protein complex located in their plasma membrane, which modulates the expression of genes important for phosphate uptake and metabolism (pho pathway). Database searches based on amino acid sequence conservation alone have been unable to identify metazoan orthologs of the bacterial and yeast phosphate sensors. Thus little is known about how human and other metazoan cells sense inorganic phosphate to regulate the effects of phosphate on cell metabolism (“metabolic” sensing) or to regulate the levels of extracellular phosphate via feedback system(s) (“endocrine” sensing). Whether the “metabolic” and the “endocrine” sensor use the same or different signal transduction cascades is unknown. This chapter will review the bacterial and yeast phosphate sensors, and then discuss what is currently known about the metabolic and endocrine effects of phosphate in multicellular organisms and humans.
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DOI：
10.1073/pnas.0704446104
发表时间：
2007-06-26
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
4.8
作者：
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影响因子：
5.8
作者：
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通讯作者：
Jueppner, Harald
影响因子：
4.8
作者：
Bai, XY;Miao, DS;Karaplis, AC
通讯作者：
Karaplis, AC