Clonostachysins A and B, new anti-dinoflagellate cyclic peptides from a marine-derived fungus
Clonostachysins A and B, new anti-dinoflagellate cyclic peptides from a marine-derived fungus
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DOI：
10.1038/ja.2005.17
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发表时间：
2005-02-01
影响因子：
3.3
通讯作者：
Shizuri, Y
中科院分区：
文献类型：
--
作者：
Adachi, K;Kanoh, K;Shizuri, Y
两种新的抗鞭毛菌抑藻素A和抑藻素B从海绵体源真菌HJK9中分离得到。它们的化学结构通过光谱研究确定为9种氨基酸的高度n甲基化环肽。用先进的Marfey方法阐明了绝对立体化学。抑藻素A和抑藻素B在30 muM条件下对一种鞭毛藻micans原心菌有选择性抑制作用，而在100 muM条件下对其他微藻和细菌无抑制作用。
The two new anti-dinoflagellates, clonostachysins A and B, were obtained from a marine sponge derived fungus Clonostachys rogersoniana strain HJK9. Their chemical structures were determined by spectroscopic studies as highly N-methylated cyclic peptides of the nine amino acids. The absolute stereochemistry was elucidated by the advanced Marfey's method. Both clonostachysins A and B exhibited a selectively inhibitory effect on a dinoflagellate Prorocentrum micans at 30 muM, but had no effect on other microalgae and bacteria even at 100 muM.