Chemical exposures and risk of chronic lymphocytic leukaemia
Chemical exposures and risk of chronic lymphocytic leukaemia
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DOI：
10.1111/j.1365-2141.2007.06874.x
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发表时间：
2007-12-01
影响因子：
6.5
通讯作者：
Baris, Dalsu
中科院分区：
文献类型：
--
作者：
Blair, Aaron;Purdue, Mark P.;Baris, Dalsu
关于化学物质在人类慢性淋巴细胞白血病(CLL)和单克隆性B细胞淋巴细胞增多症发生中的作用的文献很少。这项研究因这些结果的罕见以及随着时间的推移而使用的不同疾病分类而变得复杂。几项研究已经注意到农民中存在过量的CLL，少数研究指出了特定的化学物质。报告显示，橡胶和石油行业的CLL比率上升，表明溶剂和其他化学品可能起到了作用。少数专注于特定化学品的研究表明，应更仔细地评估CLL可能接触的化学品和溶剂，特别是苯和丁二烯。联合体内CLL研究的汇集分析提供了一个机会，通过改进的统计能力来调查化学品暴露的可能病因学作用。
Literature on the role of chemicals in the development of chronic lymphocytic leukaemia (CLL) and monoclonal B-cell lymphocytosis in humans is sparse. This research is complicated by the rarity of these outcomes and the different disease classifications used over time. Several studies have noted excesses of CLL among farmers and a few have pointed to specific chemicals. Reports suggesting elevated CLL rates in the rubber and petroleum industries point to a possible role for solvents and other chemicals. The few studies that focus on specific chemicals suggest that CLL should be more carefully evaluated in relation to possible exposure to chemicals and solvents, particularly for benzene and butadiene. Pooled analyses of CLL studies within consortia offer an opportunity to investigate the possible aetiological role of chemical exposures with improved statistical power.