Clinical impact of FDG-PET imaging cervical cancer: From in post-therapy surveillance of uterine diagnosis to prognosis
Clinical impact of FDG-PET imaging cervical cancer: From in post-therapy surveillance of uterine diagnosis to prognosis
复制标题
DOI：
10.1016/j.ygyno.2006.02.016
复制
发表时间：
2006-10-01
影响因子：
4.7
通讯作者：
Park, Sang-Yoon
中科院分区：
文献类型：
--
作者：
Chung, Hyun Hoon;Kim, Seok-Ki;Park, Sang-Yoon
目标。评估全身 2-[F-18]-氟-2-脱氧-D-葡萄糖 (FDG) 正电子发射断层扫描 (PET) 扫描在明确治疗后随访期间检测女性复发性宫颈癌的能力。方法。我们回顾性地回顾了2001年9月1日至2004年10月31日期间对初次治疗后达到完全缓解的女性进行的全身FDG-PET扫描，以检测复发性宫颈癌。结果。本研究共有 121 名连续患者登记，其中 76 名女性被诊断为复发，其中 20 名无症状。 FDG-PET 扫描在 76 名复发性疾病患者中检测出 73 名患者（96.1%），并在 45 名未复发患者中区分出 38 名患者（84.4%）。 FDG-PET扫描评估宫颈癌患者复发的敏感性、特异性和准确性分别为96.1%、84.4%和91.7%。 16例FDG-PET扫描无远处转移证据的患者接受盆腔廓清术； 6 名患者（37.5%）获得完全缓解，并且全部存活，没有疾病证据。 20名无症状复发性疾病患者中，FDG-PET扫描检测到17名（85.0%）FDG亲和性病变，8名（40.0%）患者接受了治愈性治疗；五名 (25.0%) 患者获得完全缓解，并且全部存活，没有疾病证据。本研究的三年总生存率为85.6%。结论。全身 FDG-PET 扫描是一种敏感的治疗后监测方式，即使在无症状患者中也可检测复发性宫颈癌，并有助于决定治疗计划，最终可能对预后和生存产生有利影响。 (c) 2006 年，爱思唯尔公司出版。
Objectives. To evaluate the ability of whole-body 2-[F-18]-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) scan to detect recurrent cervical cancer in women during follow-up after definitive treatment.Methods. We retrospectively reviewed the whole-body FDG-PET scan of the women who had reached complete response after primary treatment for detection of recurrent cervical cancer between September 1, 2001 and October 31, 2004.Results. One hundred twenty-one consecutive patients were registered for the current study and seventy-six women were diagnosed as recurrence, twenty of which were asymptomatic. The FDG-PET scan detected 73 (96.1%) patients among 76 patients with recurrent disease and discriminated 38 (84.4%) patients among 45 patients without recurrence. The sensitivity, specificity and accuracy of the FDG-PET scan in assessment of recurrence among patients with cervical cancer were 96.1%, 84.4% and 91.7% respectively. Sixteen patients with no evidence of distant metastasis on FDG-PET scan received pelvic exenteration; complete response was achieved in 6 (37.5%) patients, and all are alive with no evidence of disease. The FDG-PET scan detected FDG-avid lesions in 17 (85.0%) of the 20,asymptomatic patients with recurrent disease, and 8 (40.0%) patients received therapy with curative intent; complete response was achieved in five (25.0%) patients and all are alive with no evidence of disease. Three-year overall survival of this study was 85.6%.Conclusions. The whole-body FDG-PET scan is a sensitive post-therapy surveillance modality for detection of recurrent cervical cancer even in asymptomatic patients and aids in deciding treatment plans and, eventually, may have favorable impact on prognosis and survival. (c) 2006 Published by Elsevier Inc.