Relationship between NRT measurements and behavioral levels in children with the Nucleus 24 cochlear implant may change over time: preliminary report
Relationship between NRT measurements and behavioral levels in children with the Nucleus 24 cochlear implant may change over time: preliminary report
复制标题
DOI：
10.1016/s0165-5876(01)00426-8
复制
发表时间：
2001-04-27
影响因子：
1.5
通讯作者：
Collet, L
中科院分区：
文献类型：
--
作者：
Thai-Van, H;Chanal, JM;Collet, L
目的：应用神经反应遥测系统测量螺旋神经节细胞对电刺激的反应。这项研究的目的是在儿童中评估神经反应阈值和用于人工耳蜗编程过程的行为水平之间的相关性。方法：对23例人工耳蜗术前平均年龄4岁的儿童进行神经反应遥测测试。测试了4个耳内电极(电极5、10、15和20)。将植入后3，6，9，12个月的神经反应阈值与同期估计的行为阈值和最大舒适度进行比较：对每个被测电极进行皮尔逊相关性检验。结果：在顶端电极上，植入后3~12个月与行为阈值的相关性仍然显著(r范围为0.696~0.909，P<；0.05)，在整个研究期间，除电极15在9个月时外，与最大舒适程度的相关性也是显著的(有统计学意义)。在基础电极和中间电极上，只有在某些时间点才发现统计相关：然而，在植入后12个月，电极15(r=0.914-0.778，P<0.05)和电极10(r=0.845-0.720，P<；0.05)与行为水平明显相关。结论：这项初步研究表明，神经反应阈值和行为水平之间的相关性可能会从耳蜗底向顶端改善。然而，在植入后12个月，所有被测电极都有显著的相关性。在植入后的头几个月，在解释神经反应遥测测量结果时必须谨慎：阳性测试并不一定意味着传递到听神经的刺激将与听觉感知的结果一起进行中央处理。(C)2001爱思唯尔爱尔兰科学有限公司。保留所有权利。
Objective: Response from spiral ganglion cells to electrical stimulation via the Nucleus 24 cochlear implant can be measured using the neural response telemetry system. The purpose of this study was to assess, in children, the correlation between the neural response threshold and the behavioral levels used for cochlear implant programming process. Methods: The neural response telemetry test was administered to 23 children (mean age at implantation: 4 years) with the Nucleus 24 cochlear implant. Four intra-cochlear electrodes (electrodes 5, 10, 15 and 20) were tested. The neural response threshold at 3, 6, 9 and 12 months post-implantation was compared with the behavioral threshold and the maximum comfort level estimated during the same periods: a Pearson's correlation test was performed for each tested electrode. Results: On apical electrodes, the correlation with the behavioral threshold remained significant from 3 to 12 months post-implantation (r ranging from 0.696 to 0.909, P < 0.05), and the correlation with the maximum comfort level was also significant throughout the study period, except on electrode 15 at 9 months (tendency to significance). On basal and intermediate electrodes, statistical correlations were found only at some points of time: nonetheless, at 12 months post-implantation, a significant correlation with behavioral levels could be clearly demonstrated both on electrode 15 (r = 0.914-0.778, P < 0.05) and on electrode 10 (r = 0.845-0.720, P < 0.05). Conclusions: This preliminary study suggests that the correlation between the neural response threshold and behavioral levels may improve from the base towards the apex of the cochlea. However, a significant correlation can be demonstrated for all tested electrodes at 12 months post-implantation. During the first months post-implantation care must be exercised when interpreting neural response telemetry measurements: a positive test does not necessarily mean that the stimulus delivered to the acoustic nerve will be centrally processed with the result of an auditory perception. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.