Synthesis of conformationally locked versions of puromycin analogues.
Synthesis of conformationally locked versions of puromycin analogues.
复制标题
嘌呤霉素类似物构象锁定版本的合成。
DOI：
10.1021/jo8016132
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Marquez,VictorE
中科院分区：
文献类型：
--
作者：
Saneyoshi,Hisao;Michel,BenoîtY;Choi,Yongseok;Strazewski,Peter;Marquez,VictorE
Conformationally lockedNorthandSouthversions of puromycin analogues built on a bicyclo[3.1.0]hexane pseudosugar template were synthesized. The final assembly of the products was accomplished by the Staudinger−Vilarrasa coupling of the correspondingNorth(2and3) andSouth(6and7) 3′-azidopurine carbanucleosides with the Fmoc-protected 1-hydroxybenzotriazole ester of 4-methoxy-l-tyrosine.Northazides2and3were reported earlier. The 3′-azido intermediates6and7that are necessary for the synthesis of theSouthpuromycin analogues are described herein for the first time.
