Microglial mitophagy mitigates neuroinflammation in Alzheimer's disease
Microglial mitophagy mitigates neuroinflammation in Alzheimer's disease
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DOI：
10.1016/j.neuint.2019.104469
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发表时间：
2019-10-01
影响因子：
4.2
通讯作者：
Fang, Evandro F.
中科院分区：
文献类型：
--
作者：
Lautrup, Sofie;Lou, Guofeng;Fang, Evandro F.
在神经元中，有缺陷的线粒体自噬导致受损线粒体的积累，并最终导致各种神经退行性疾病，包括阿尔茨海默病（AD）。然而，线粒体自噬在AD中是如何有缺陷的以及有缺陷的线粒体自噬如何导致AD还没有完全理解。我们对这一主题的最新进展进行了评论，强调线粒体自噬不仅在神经元中，而且在小胶质细胞中，在不同的AD动物模型中预防病理和认知能力下降的重要性。
In neurons, defective mitophagy results in accumulation of damaged mitochondria, and finally leading to various neurodegenerative diseases, including Alzheimer's disease (AD). However, how mitophagy is defective in AD as well as how defective mitophagy contributes to AD is not fully understood. We give commentary on recent progress of this topic, highlighting the importance of mitophagy not only in neurons, but also in microglia, in forestalling pathology and cognitive decline in different animal models of AD.