Zinc-enriched amygdalo- and hippocampo-cortical connections to the inferotemporal cortices in macaque monkey
Zinc-enriched amygdalo- and hippocampo-cortical connections to the inferotemporal cortices in macaque monkey
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DOI：
10.1016/j.neures.2005.06.002
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发表时间：
2005-09-01
影响因子：
2.9
通讯作者：
Rockland, KS
中科院分区：
文献类型：
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作者：
Ichinohe, N;Rockland, KS
突触锌 (Zn) 是一些谷氨酸能突触的辅助因子，与可塑性效应以及几种兴奋性毒性和其他病理生理状况有关。在这项研究中，我们提供了有关颞下皮质（视觉和海马网络交界处的区域）中锌分布的信息。简而言之，我们发现 Zn 从外侧到内侧增加，其中 TEad（单峰视觉区域）显示出较低水平的 Zn； TEav，中级；和嗅周皮层，一个多模态边缘区域，水平很高。小白蛋白（一种钙结合蛋白）的分布与锌的分布呈相反梯度。通过皮质内注射亚硒酸钠 (Na2SeO3) 来鉴定 Zn+ 终止起源的神经元。该物质与 Zn 相互作用形成 ZnSe 沉淀物，并以这种形式逆行转运至体细胞。标记神经元的混合群体被可视化，其中包括海马 CA1 和几个杏仁核亚核中的 Zn+ 神经元。在 CA1 中，Zn+ 神经元仅限于锥体层的上部。锌被认为有助于活动依赖性突触可塑性。鼻周皮层中特别高的水平及其起源于 CA I 和杏仁核中的神经元，可能与视觉长期记忆形成中涉及的细胞事件有关。 (c) 2005 年爱思唯尔爱尔兰有限公司和日本神经科学学会。版权所有。
Synaptic zinc (Zn), a co-factor in some glutamatergic synapses, has been implicated in plasticity effects, as well as in several excitotoxic and other pathophysiological conditions. In this study, we provide information about the distribution of Zn in inferotemporal cortex, a region at the interface of the visual and hippocampal networks. In brief, we found a lateral to medial increase in Zn, where TEad, a unimodal visual area, showed low levels of Zn; TEav, intermediate levels; and perirhinal cortex, a multimodal limbic area, high levels. The distribution of parvalbumin, a calcium binding protein, showed a reverse gradient to that of Zn. The neurons of origin of the Zn+ termination were identified by making intracortical injections sodium selenite (Na2SeO3). This substance interacts with Zn to form precipitates of ZnSe and in this form is transported retrogradely to the soma. A mixed population of labeled neurons was visualized, which included Zn+ neurons in CAl of the hippocampus and in several amygdala subnuclei. In CAl, Zn+ neurons were restricted to the upper part of stratum pyramidale. Zn is thought to contribute to activity-dependent synaptic plasticity. The specifically high level in perirhinal cortex, and its origin from neurons in CA I and the amygdala, may relate to cellular events involved in visual long-term memory formation. (c) 2005 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.