Pseudoexfoliation syndrome prevalence in Greek patients with cataract and its association to glaucoma and coronary artery disease
Pseudoexfoliation syndrome prevalence in Greek patients with cataract and its association to glaucoma and coronary artery disease
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DOI：
10.1038/sj.eye.6702992
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发表时间：
2009-02-01
期刊：
影响因子：
3.9
通讯作者：
Gartaganis, S. P.
中科院分区：
文献类型：
--
作者：
Andrikopoulos, G. K.;Mela, E. K.;Gartaganis, S. P.
目的探讨青光眼和冠状动脉疾病（CAD）的患病率与白内障和假性剥脱（PEX）syndrome.Methods的2140例连续白内障患者在帕特雷大学医院，希腊，白内障手术的横断面研究。本研究仅纳入老年性白内障患者。所有患者均接受了完整的眼科检查，包括裂隙灯评价，散瞳检查前段中的PEX材料，眼内压（IOP）测量和视盘杯检查。他们还接受了心脏病专家对CAD的评估。如果患者有心肌梗死、缺血或冠状动脉造影异常病史，则认为存在CAD。结果男性1088例（50.8%），女性1052例（49.2%）。PEX综合征的总患病率为27.9%，并随着年龄的增长而增加。双侧PEX发生率高于单侧PEX，且双侧PEX发生率随年龄增长而升高。PEX组共有132名患者（22.1%）患有青光眼，而非PEX组仅2.5%患有青光眼。在50岁或50岁以上的受试者中，还发现PEX与CAD风险呈正相关。结论PEX综合征是青光眼的主要危险因素，也是CAD的危险因素。PEX患者应被告知并经常检查，因为风险始终存在。
Purpose To investigate the prevalence of glaucoma and coronary artery disease (CAD) in patients with cataract and pseudoexfoliation (PEX) syndrome.Methods Cross-sectional study of 2140 consecutive patients with cataract admitted at the University Hospital of Patras, Greece, for cataract surgery. Only patients with senile cataract were included in this study. All patients underwent a complete ophthalmological examination that included slit-lamp evaluation with dilated pupil for PEX material in the anterior segment, intraocular pressure (IOP) measurements, and optic disc cup examination. They also underwent an evaluation for CAD by a cardiologist. CAD was considered present if a patient had a history of myocardial infarction, or ischaemia, or abnormal coronary angiography. The patients were classified into two groups: the PEX and the non-PEX group.Results One thousand and eighty-eight (50.8%) patients were men and 1052 (49.2%) were women. The overall prevalence of PEX syndrome was found to be 27.9% and it was found to increase with progressing age. Bilateral PEX was more frequent than unilateral PEX, with the percentage of bilateral PEX raising with progressing age. A total of 132 patients (22.1%) in the PEX group exhibited glaucoma, while in the non-PEX group only 2.5% suffered glaucoma. PEX was also found to be positively associated with the risk for CAD among subjects 50 years or older. No association between CAD and glaucoma was found.Conclusions PEX syndrome constitutes a major glaucoma risk factor and a CAD risk factor. Patients with PEX should be informed and examined frequently as the risk is present throughout.