Effects of Estrogen and Sex Difference on Secretion of Human Growth Hormone1
Effects of Estrogen and Sex Difference on Secretion of Human Growth Hormone1
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雌激素和性别差异对人类生长激素分泌的影响1
DOI：
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发表时间：
1965
期刊：
影响因子：
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通讯作者：
M. Rabkin
中科院分区：
文献类型：
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作者：
A. Frantz;M. Rabkin
在禁食受试者醒来时和正常活动后1-3小时后测量了血浆中的人类生长激素（HGH）。男性和女性的基础水平没有差异，通常低于1 μg/ml。女性中晚期（“门诊”）标本的平均水平显著升高至6.5 μg/ml。这种升高在男性中未观察到，其基础值和动态值无法区分。给予男性雌激素导致活动后HGH增加的正常女性模式的再现。在整个月经周期中，观察到女性的动态而非基础HGH变化，排卵后不久开始明显的黄体期上升。据推测，（a）雌激素的作用，以提高垂体的敏感性，或更高的中心，对生长激素释放的影响，体力活动和可能的其他刺激;和（B），这种影响可能是至少部分负责的差异，血浆生长激素注意到男性和女性之间，和…
Human growth hormone (HGH) has been measured in the plasma of fasting subjects at the moment of awaking and 1–3 hr later after normal activity. Basal levels of men and women were not different and were usually less than 1 mμg/ml. A marked rise in the later (“ambulatory”) specimens occurred in women, to a mean level of 6.5 mμg/ml. This rise was not seen in men, whose basal and ambulatory values were indistinguishable. Administration of estrogen to men resulted in a reproduction of the normal female pattern of HGH increase after activity. Variations of ambulatory but not basal HGH were noted in women followed throughout the menstrual cycle, with a distinct luteal phase rise beginning shortly after ovulation. It is postulated (a) that estrogens act to enhance pituitary sensitivity, or that of higher centers, to the HGH-releasing effects of physical activity and possibly other stimuli; and (b) that this effect may be at least partly responsible for the differences in plasma HGH noted between men and women, an...