Carbon Dots with Intrinsic Bioactivities for Photothermal Optical Coherence Tomography, Tumor-Specific Therapy and Postoperative Wound Management
Carbon Dots with Intrinsic Bioactivities for Photothermal Optical Coherence Tomography, Tumor-Specific Therapy and Postoperative Wound Management
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具有内在生物活性的碳点，用于光热光学相干断层扫描、肿瘤特异性治疗和术后伤口处理
DOI：
10.1002/adhm.202101448
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发表时间：
2022-01-07
影响因子：
10
通讯作者：
Liu, Zhiming
中科院分区：
文献类型：
--
作者：
Liu, Hao;Mo, Luoqi;Liu, Zhiming
碳点(Cd)被认为是具有优异生物相容性的多模型癌症治疗药物的候选材料。然而，为了提高治疗效果，常常需要加入外源性成分，如靶向分子和化疗/光治疗药物。在此，提出了一种“一体式”CD，它具有生物成像、有效的肿瘤治疗和术后处理的内在生物活性。由没食子酸和酪氨酸衍生的多功能硫化镉(GT-CDS)由石墨化的碳核和富含N，O的官能团组成，使其具有高达33.9%的近红外光热转化率和肿瘤特异性细胞毒性。介绍了一种新的成像方式--光热光学相干层析成像，它以GT-CDS为造影剂，提供了微米级分辨率的肿瘤组织三维形态。在肿瘤治疗方面，GT-CDS可在肿瘤细胞内启动活性氧的产生，而不是在正常细胞内，进一步诱导线粒体崩溃和随后的肿瘤细胞凋亡。与近红外光热治疗相结合，实现了体内外协同抗肿瘤治疗。GT-CDs还可以促进细菌污染的皮肤伤口的愈合过程，显示出它们预防术后感染的潜力。基于通用GT-CDS的集成治疗策略为疾病管理提供了一种替代的易于处理的模式。
Carbon dots (CDs) are considered as promising candidates with superior biocompatibilities for multimodel cancer theranostics. However, incorporation of exogenous components, such as targeting molecules and chemo/photo therapeutic drugs, is often required to improve the therapeutic efficacy. Herein, an "all-in-one" CDs that exhibit intrinsic bioactivities for bioimaging, potent tumor therapy, and postoperative management is proposed. The multifunctional CDs derived from gallic acid and tyrosine (GT-CDs) consist of a graphitized carbon core and N, O-rich functional groups, which endow them with a high near-infrared (NIR) photothermal conversion efficiency of 33.9% and tumor-specific cytotoxicity, respectively. A new imaging modality, photothermal optical coherence tomography, is introduced using GT-CDs as the contrast agent, offering the micrometer-scale resolution 3D tissue morphology of tumor. For cancer therapy, GT-CDs initiate the intracellular generation of reactive oxygen species in tumor cells but not normal cells, further induce the mitochondrial collapse and subsequent tumor cellular apoptosis. Combined with NIR photothermal treatment, synergistic antitumor therapy is achieved in vitro and in vivo. GT-CDs also promote the healing process of bacteria-contaminated skin wound, demonstrating their potential to prevent postoperative infection. The integrated theranostic strategy based on versatile GT-CDs supplies an alternative easy-to-handle pattern for disease management.