Direct effect of physiological doses of arginine vasopressin on the arterial wall in vivo.
Direct effect of physiological doses of arginine vasopressin on the arterial wall in vivo.
复制标题
生理剂量的精氨酸加压素对体内动脉壁的直接影响。
DOI：
10.1152/ajpheart.1978.234.2.h167
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发表时间：
1978
期刊：
影响因子：
--
通讯作者：
L. H. Peterson
中科院分区：
文献类型：
--
作者：
E. Monos;R. Cox;L. H. Peterson
在麻醉狗垂体切除术前后，研究了局部应用血药浓度为100-150 μ U/ml的精氨酸加压素（VPA）对手术失神经支配的颈总动脉（CC）和股动脉（FA）外径（D）和动态弹性模量（E*）的影响。还测定了切除垂体前后CC和FA血管床的D、E* 和流动阻力（R）的变化。研究发现，VPA引起E* 显著（最大21-26%）降低和FA的D较小（最大5.9-6.9%）降低，与是否存在垂体无关。垂体切除后VPA效应的发展比切除前更快。在CC中，VPA对E* 值无显著影响。在垂体切除术后1小时内，观察到E*-CC，E*-FA和D-CC的统计学显著降低，但D-FA没有变化，尽管动脉压以及R-FA和R-CC减少。这些结果进一步支持VPA的生理血管作用和在短期循环控制中的可能作用。在大动脉中，VPA的作用似乎也存在区域差异。
Effects of topically applied arginine vasopressin (VPA), in 100-150 muU/ml blood concentration, on external diameter (D) and on dynamic elastic modulus (E*) of surgically denervated common carotid (CC) and femoral (FA) arteries have been studied before and after hypophysectomy in anesthetized dogs. Changes in D, E*, and flow resistance (R) of the CC and FA vascular beds before and after removal of the pituitary were also determined. It was found that VPA elicited a substantial (max 21-26%) decrease in E* and a smaller (max 5.9-6.9%) reduction in D of FA independent of the presence of absence of the pituitary gland. The VPA effect developed more rapidly after hypophysectomy than before. In the CC, VPA did not significantly affect values of E*. During the 1-h period after hypophysectomy, statistically significant decreases in E*-CC, E*-FA, and D-CC were observed, but D-FA did not change, although arterial pressure as well as R-FA and R-CC were diminished. These results give further support to physiological vascular actions of VPA and a possible role in short-term circulatory control. In large arteries, the effects of VPA also seem to be regionally differentiated.