Emerging immunological targets in inflammatory bowel disease
Emerging immunological targets in inflammatory bowel disease
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DOI：
10.1016/j.coph.2011.09.013
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发表时间：
2011-12-01
影响因子：
4
通讯作者：
MacDonald, Thomas T.
中科院分区：
文献类型：
--
作者：
Monteleone, Giovanni;Pallone, Francesco;MacDonald, Thomas T.
克罗恩病(CD)和溃疡性结肠炎(UC)是人类炎症性肠病(IBD)的主要形式。它们是由肠道衬里和更深层的损伤引起的，这是由于针对肠道微生物区系成分的过度免疫反应，以及反调节机制控制不力。然而，CD和UC在免疫学上是不同的。CD相关性炎症的特点是粘膜内有大量分泌辅助性T细胞(Th)1和Th17细胞因子的T淋巴细胞。UC患者的局部免疫反应极化程度较低，但可能表现为IL-5、IL-13和Th17细胞因子的产生增强。然而，在下游，CD和UC共享重要的肠道损伤的终末效应通路，由免疫和非免疫细胞之间的活跃串扰介导。对IBD患者肠道中复杂的免疫-炎症介质网络的澄清导致了新靶点的确定，这些新靶点应该有助于开发新的生物疗法。
Crohn's disease (CD) and ulcerative colitis (UC) are the major forms of inflammatory bowel diseases (IBD) in man. They are caused by damage to the lining of the intestine and deeper layers, due to an excessive immune response directed against components of the gut microflora and poorly controlled by counter-regulatory mechanisms. CD and UC are however immunologically distinct. CD-related inflammation is characterized by a marked mucosal infiltration of T lymphocytes secreting T helper type (Th) 1 and Th17 cytokines. In UC, the local immune response is less polarized but may show enhanced production of IL-5, IL-13 and Th17 cytokines. Downstream however CD and UC share important end-stage effector pathways of intestinal injury, mediated by an active cross-talk between immune and non-immune cells. The clarification of the complex networks of immune-inflammatory mediators operating in the gut of IBD patients has led to the identification of new targets that should facilitate the development of novel biological therapies.