Dynamics of leukocyte receptors after severe burns: An exploratory study

Dynamics of leukocyte receptors after severe burns: An exploratory study
复制标题

DOI：
10.1016/j.burns.2010.08.015
复制
发表时间：
2011-03-01
期刊：
BURNS
影响因子：
2.7
通讯作者：
Sjoberg, Folke
Sjoberg, Folke
中科院分区：
医学3区
文献类型：
--
作者：
Johansson, Joakim;Sjogren, Florence;Sjoberg, Folke

文献摘要

被引文献

相似文献

背景：烧伤患者易发生器官衰竭，有间接证据表明白细胞可能参与了这一过程。它们可能在某些刺激（例如烧伤）后改变细胞表面受体的表达。因此，我们旨在评估烧伤引起的PMNs和单核细胞表面白细胞表面受体CD11b、CD14、CD16和CD62L表达的变化。我们还想在烧伤后的第一周检查这种激活的动态，并将其与损伤的大小联系起来。方法：选取10例颅脑损伤15% （TBSA）烧伤患者作为研究对象。在第一周到达时和连续每天早晨采集血样。健康志愿者作为对照。结果：PMN CD11b表达升高。PMN CD11b表达程度与全层烧伤大小呈负相关。单核细胞CD14表达最初升高，但与烧伤大小无关。PMN CD16表达在第1天呈下降趋势，与烧伤大小有关。在烧伤后的第一周内，PMN或单核细胞中的CD62L不随烧伤而变化。结论：本研究表明，烧伤对白细胞表面特异性受体（PMN CD11b、单核细胞CD14和PMN CD16）有影响。PMN CD11b和CD16的表达与烧伤大小有关。烧伤对PMN受体（如PMN CD11b和CD16）表达的影响可能有助于烧伤诱导的感染易感性。(C) 2010 Elsevier Ltd和ISBI。版权所有。
Background: Patients with burns are susceptible to organ failure, and there is indirect evidence that leukocytes may contribute to this process. They may change the expression of cell-surface receptors after certain stimuli, for example, the burn. We therefore aimed to assess the changes induced by the burn in the expression of leukocyte cell-surface receptors CD11b, CD14, CD16, and CD62L on the surface of PMNs and monocytes. We also wanted to examine the dynamics of this activation during the first week after the burn, and to relate it to the size of the injury.Methods: Ten patients with burns of >15% (TBSA) were included in the study. Blood samples were collected on arrival and every consecutive morning during the first week. Healthy volunteers acted as controls.Results: PMN CD11b expression was increased. The extent of PMN CD11b expression correlated negatively to the size of the full thickness burn. Monocyte CD14 expression increased initially but there was no relation to the size of the burn. PMN CD16 expression decreased initially during the first days and the decrease was related to burn size. CD62L did not vary depending on the burn in either PMN or monocytes during the first week after the burn.Conclusion: This study showed that specific receptors on the surface of leukocytes (PMN CD11b, monocyte CD14 and PMN CD16) are affected by the burn. Expression of PMN CD11b and CD16 are related to burn size. Burn-induced effects on the expression of PMN receptors, such as PMN CD11b and CD16, may contribute to burn-induced infection susceptibility. (C) 2010 Elsevier Ltd and ISBI. All rights reserved.