Lipid levels and the risk of hemorrhagic stroke among women
Lipid levels and the risk of hemorrhagic stroke among women
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DOI：
10.1212/wnl.0000000000007454
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发表时间：
2019-05-07
期刊：
影响因子：
9.9
通讯作者：
Rexrode, Kathryn M.
中科院分区：
文献类型：
--
作者：
Rist, Pamela M.;Buring, Julie E.;Rexrode, Kathryn M.
目的探讨血脂水平与女性出血性中风风险之间的关系。方法我们对27937名参加《女性健康研究》的女性进行了前瞻性队列研究，测量了总胆固醇、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDLC)以及甘油三酯。中风通过病历复查得到确认。我们使用COX比例风险模型分析血脂类别与出血性卒中风险之间的关系。结果在平均19.3年的随访期中，137例出血性卒中发生。与低密度脂蛋白胆固醇水平100~129.9 mg/dL相比，经多因素调整后，低密度脂蛋白胆固醇水平=160 mg/dL(RR1.53；95%CI0.92，2.52)。经多变量调整后，甘油三酯水平最低四分之一的女性与甘油三酯水平最高的女性相比，出血性中风的风险显著增加(相对危险度2.00；95%可信区间1.18，3.39)。我们没有观察到总胆固醇或高密度脂蛋白胆固醇水平与出血性卒中风险之间的显著关联。结论低密度脂蛋白胆固醇水平和低甘油三酯水平与女性出血性卒中风险增加有关。
ObjectiveTo examine the association between lipid levels and hemorrhagic stroke risk among women.MethodsWe performed a prospective cohort study among 27,937 women enrolled in the Women's Health Study with measured total cholesterol, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C), as well as triglycerides. Strokes were confirmed by medical record review. We used Cox proportional hazards models to analyze associations between lipid categories and hemorrhagic stroke risk.ResultsDuring a mean of 19.3 years of follow-up, 137 hemorrhagic strokes occurred. Compared to those with LDL-C levels 100-129.9 mg/dL, after multivariable adjustment, those with LDL-C levels = 160 mg/dL (RR 1.53; 95% CI 0.92, 2.52). Women in the lowest quartile of triglycerides had a significantly increased risk of hemorrhagic stroke compared to women in the top quartile after multivariable adjustment (RR 2.00; 95% CI 1.18, 3.39). We observed no significant associations between total cholesterol or HDL-C levels and hemorrhagic stroke risk.ConclusionLDL-C levels < 70 mg/dL and low triglyceride levels were associated with increased risk of hemorrhagic stroke among women.