Development of Oral Delivery Systems with Enhanced Antioxidant and Anticancer Activity: Coix Seed Oil and β-Carotene Coloaded Liposomes
Development of Oral Delivery Systems with Enhanced Antioxidant and Anticancer Activity: Coix Seed Oil and β-Carotene Coloaded Liposomes
复制标题
开发具有增强抗氧化和抗癌活性的口服给药系统：薏苡仁油和β-胡萝卜素共载脂质体
DOI：
10.1021/acs.jafc.8b04879
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发表时间：
2019-01-09
影响因子：
6.1
通讯作者：
McClements, David Julian
中科院分区：
文献类型：
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作者：
Bai, Chunqing;Zhen, Jingxia;McClements, David Julian
用生物活性制剂组合来强化食品和饮料产品是食品工业中的一项重大举措，因为它们对人类健康具有潜在的添加剂甚至协同效益。据报道，薏苡仁油（CSO）具有抗癌活性，而β -胡萝卜素（β C）是一种天然抗氧化剂，也可能具有抗癌活性。然而，这两种生物活性物质都不溶于水，口服生物利用度很差。本研究的目的是通过将β C和CSO包封到脂质体（l - β C-CSO）中来克服这些障碍。然后测定了两种生物活性剂不同组合对脂质体的理化性质、稳定性、释放、抗氧化活性和抗癌活性的影响。CSO水平的提高降低了β - C的捕获效率，增加了颗粒大小，降低了多分散性，提高了生物活性负载脂质体的表面电位大小。此外，β C和CSO水平影响它们在脂质双分子层内的取向，这也影响了系统的理化性质、稳定性和体外释放行为。与含有单一生物活性类型的脂质体相比，联合体系具有更高的生物利用度和更高的抗癌和抗氧化活性。这些结果表明，复合生物活性脂质体可能是一种有效的配方，在功能食品和补充剂中有潜在的应用。
Fortifying food and beverage products with combinations of bioactive agents is a major initiative within the food industry because of their potentially additive or even synergistic benefits for human health. Coix seed oil (CSO) has been reported to possess anticancer activity, whereas beta-carotene (beta C) is a natural antioxidant that may also exhibit anticancer activity. However, both of these bioactives are insoluble in water and have poor oral bioavailability. The aim of this study was to overcome these obstacles by encapsulating both beta C and CSO into liposomes (L-beta C-CSO). The effect of different combinations of these two bioactive agents on the physiochemical properties, stability, release, antioxidant activity, and anticancer activity of the liposomes was then determined. Increasing the CSO level decreased the beta C entrapment efficiency, increased the particle size, reduced the polydispersity, and raised the magnitude of the surface potential of the bioactive-loaded liposomes. Moreover, the beta C and CSO levels affected their orientation within the lipid bilayer, which also influences the physiochemical properties, stability, and in vitro release behavior of the system. Compared to liposomes containing single bioactive types, the combined systems exhibited higher bioavailability and increased anticancer and antioxidant activity. These results suggest that the combined bioactive-loaded liposomes could be an efficient formulation for potential applications in functional foods and supplements.