Polymeric micelles formed by polypeptide graft copolymer and its mixtures with polypeptide block copolymer
Polymeric micelles formed by polypeptide graft copolymer and its mixtures with polypeptide block copolymer
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DOI：
10.1016/j.polymer.2006.04.011
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发表时间：
2006-06-14
期刊：
影响因子：
4.6
通讯作者：
Zhang, Suning
中科院分区：
文献类型：
--
作者：
Li, Tao;Lin, Jiaping;Zhang, Suning
采用去离子水透析法制备了不同接枝度的聚（γ -苄基- l-谷氨酸）-聚乙二醇接枝共聚物（PBLG-g-PEG）和PBLG-g-PEG与聚（γ -苄基- l-谷氨酸）-聚乙二醇嵌段共聚物（PBLG-b-PEG）的聚合物胶束。利用荧光光谱和透射电子显微镜对其自组装行为进行了研究。实验结果表明，接枝程度对PBLG-g-PEG形成的胶束的临界胶束浓度（CMC）和胶束形态有显著影响。随着接枝程度的增加，CMC值变大，形成的胶束形态由不规则形状变为纺锤形。还发现PBLG-g-PEG/PBLG-b-PEG的混合物可以缔合成各种形状的杂化聚合物胶束。(c) 2006 Elsevier Ltd.版权所有。
Polymeric micelles based on poly(gamma-benzyl-L-glutaniate)-poly(ethylene glycol) graft copolymer (PBLG-g-PEG) with various degrees of grafting and the mixtures composed of PBLG-g-PEG and poly(gamma-benzyl-L-glutamate)-poly(ethylene glycol) block copolymer (PBLG-b-PEG) were prepared by the dialysis method in deionized water. Fluorescence spectroscopy and transmission electron microscope (TEM) have been used to study the self-assembly behavior. The experimental results revealed that the degree of grafting exerts marked effect on the critical micelle concentration (CMC) and the morphology of the micelle formed by PBLG-g-PEG. With increasing the degree of grafting, the CMC value becomes larger and the morphology of formed micelle changes from irregular shape to spindle. It was also found that mixtures of PBLG-g-PEG/PBLG-b-PEG can associate into hybrid polymeric micelle with various shapes. (c) 2006 Elsevier Ltd. All rights reserved.