Ordering recombinant silk-elastin-like nanofibers on the microscale.
Ordering recombinant silk-elastin-like nanofibers on the microscale.
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DOI：
10.1063/1.4863077
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发表时间：
2014-01
影响因子：
4
通讯作者：
Like Zeng;Weibing Teng;Linan Jiang;J. Cappello;Xiaoyi Wu
中科院分区：
文献类型：
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作者：
Like Zeng;Weibing Teng;Linan Jiang;J. Cappello;Xiaoyi Wu
自组装肽/多肽纳米纤维是制造复杂三维结构的有吸引力的构建块。然而，在微观尺度上将组装好的肽/多肽纳米纤维排列成三维结构仍然具有挑战性，通常需要采用自上而下的方法。我们报道了类丝弹性蛋白聚合物在生理相关条件下自组装成纳米纤维，组装后的纳米纤维在微尺度上进一步形成纤维团簇，纳米纤维团簇最终合并成具有不同纳米尺度和微尺度特征的三维结构。认为纤维生长和分子扩散之间的相互作用导致了组装的类弹性丝纳米纤维在微观尺度上的有序。
Self-assembled peptide/polypeptide nanofibers are appealing building blocks for creating complex three-dimensional structures. However, ordering assembled peptide/polypeptide nanofibers into three-dimensional structures on the microscale remains challenging and often requires the employment of top-down approaches. We report that silk-elastin-like protein polymers self-assemble into nanofibers in physiologically relevant conditions, the assembled nanofibers further form fiber clusters on the microscale, and the nanofiber clusters eventually coalesce into three-dimensional structures with distinct nanoscale and microscale features. It is believed that the interplay between fiber growth and molecular diffusion leads to the ordering of the assembled silk-elastin-like nanofibers at the microscale.