Evaluation of blood volume by use of blood oxygen level-dependent magnetic resonance imaging in a cuff-compression model: usefulness of calculated echo time image.
Evaluation of blood volume by use of blood oxygen level-dependent magnetic resonance imaging in a cuff-compression model: usefulness of calculated echo time image.
复制标题
在袖带压缩模型中使用血氧水平依赖性磁共振成像评估血容量：计算回波时间图像的有用性。
DOI：
10.1007/s11604-015-0435-0
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发表时间：
2015
期刊：
影响因子：
2.1
通讯作者：
Sugimura K
中科院分区：
文献类型：
--
作者：
Nishii T;Kono AK;Nishio M;Kyotani K;Nishiyama K;Sugimura K
目的在血氧水平依赖(BOLD)成像中，需要单独评估血氧水平和血容量的变化。我们开发了一种计算回声时间(TE)的成像技术，旨在最大限度地减少血液氧合的影响，并专门评估血容量。材料和方法采用袖带压迫模型，从6名健康志愿者身上获取小腿肌肉的动态3T多回声BOLD图像。从采集的多回声图像中计算TE=0毫秒(CTE0)和MAP()时的TE图像。获得了在TE=45.2ms(ATE45)时，整个小腿肌肉的平均值在cTE0，在获得的粗体图像中的时间进程。计算两对时间进程之间的欧几里得距离：aTE45与Dat之间的距离，cTE0与DCT之间的距离。结果Dct与Dct之间的差异有统计学意义(P=0.031)，说明cTE0与血氧加权像(ATE45)的时程有显著差异。结论cTE0可以最大限度地减少血氧变化的影响。因此，cTE0信号强度的变化更能反映血容量的变化。
PurposeSeparate assessment of changes in blood oxygenation and blood volume is required in blood oxygen level-dependent (BOLD) imaging. We developed a calculated echo time (TE) imaging technique designed to minimize effects of blood oxygenation and to evaluate blood volume specifically.Materials and methodsDynamic 3T multi-echo BOLD images of calf muscle were acquired from six healthy volunteers by use of a cuff-compression model. Calculated TE images at TE = 0 ms (cTE0) andmap () were calculated from acquired multi-echo images. The time courses of the mean value for the entire calf muscles in cTE0, in acquired BOLD images at TE = 45.2 ms (aTE45), and inwere obtained. The Euclidean distances between the two pairs of time courses were calculated: distance between aTE45and(Dat), and that between cTE0and(Dct). The difference betweenDatandDctwas tested by use of the Wilcoxon signed rank test.ResultsDatwas significantly different fromDct(P= 0.031), indicating that the time course of cTE0was significantly different from that of blood oxygenation-weighted images (and aTE45).ConclusionThe effect of blood oxygenation could be minimized using cTE0. Thus, signal intensity changes of cTE0reflected changes in blood volume more specifically.